The Beneficial Effects of Red Sun-Dried Capsicum annuum L. Cv Senise Extract with Antioxidant Properties in Experimental Obesity are Associated with Modulation of the Intestinal Microbiota.
dried red sweet peppers
hypoglycemic effect
hypolipidemic effect
inflammation
microbiomes
obesity
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
17
08
2020
revised:
12
11
2020
pubmed:
11
12
2020
medline:
3
11
2021
entrez:
10
12
2020
Statut:
ppublish
Résumé
Capsicum annuum L. cv Senise is a sweet pepper containing health promoting compounds that can be modified by ripening and drying. This study focuses on finding the peppers with the best antioxidant properties, which are evaluated on an experimental model of obesity. Phytochemical profile and antioxidant activity are evaluated on several peppers obtained from the same cultivar at different ripening stages. Red sweet peppers show the highest content in polyphenols, β-carotene, lycopene, and capsinoids, and demonstrate the best antioxidant activity in vitro. Mice fed a high fat diet are orally treated with an extract from these peppers (Capsicum annuum extract [CAE]) (1, 10, and 25 mg/kg/day). It promotes weight loss and improves plasma markers related to glucose and lipid metabolisms. CAE also ameliorates obesity-associated systemic inflammation reducing the expression of pro-inflammatory cytokines in adipose and hepatic tissues and improving the expression of different markers involved in the gut epithelial barrier function. These effects are associated with a modulation of the intestinal microbiome, which appears altered. The extract can be considered a new potential approach for the treatment of obesity, complementary to dietary restrictions.
Identifiants
pubmed: 33300660
doi: 10.1002/mnfr.202000812
doi:
Substances chimiques
Antioxidants
0
Cytokines
0
Plant Extracts
0
Carotenoids
36-88-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2000812Informations de copyright
© 2020 Wiley-VCH GmbH.
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