Ten years of enhancing neuro-imaging genetics through meta-analysis: An overview from the ENIGMA Genetics Working Group.
GWAS
MRI
neuro-imaging genetics
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
16
11
2020
received:
04
09
2020
accepted:
17
11
2020
pubmed:
11
12
2020
medline:
29
3
2022
entrez:
10
12
2020
Statut:
ppublish
Résumé
Here we review the motivation for creating the enhancing neuroimaging genetics through meta-analysis (ENIGMA) Consortium and the genetic analyses undertaken by the consortium so far. We discuss the methodological challenges, findings, and future directions of the genetics working group. A major goal of the working group is tackling the reproducibility crisis affecting "candidate gene" and genome-wide association analyses in neuroimaging. To address this, we developed harmonized analytic methods, and support their use in coordinated analyses across sites worldwide, which also makes it possible to understand heterogeneity in results across sites. These efforts have resulted in the identification of hundreds of common genomic loci robustly associated with brain structure. We have found both pleiotropic and specific genetic effects associated with brain structures, as well as genetic correlations with psychiatric and neurological diseases.
Identifiants
pubmed: 33300665
doi: 10.1002/hbm.25311
pmc: PMC8675405
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
292-299Subventions
Organisme : NIH HHS
ID : EB020403
Pays : United States
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Informations de copyright
© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
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