Towards an accurate and systematic characterisation of persistently asymptomatic infection with SARS-CoV-2.

Asymptomatic Infections / epidemiology COVID-19 / diagnosis Humans Pandemics Retrospective Studies SARS-CoV-2 Serologic Tests

Journal

The Lancet. Infectious diseases
ISSN: 1474-4457
Titre abrégé: Lancet Infect Dis
Pays: United States
ID NLM: 101130150

Informations de publication

Date de publication:
06 2021
Historique:
received: 06 08 2020
revised: 06 10 2020
accepted: 07 10 2020
pubmed: 11 12 2020
medline: 2 7 2021
entrez: 10 12 2020
Statut: ppublish

Résumé

People with persistently asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection experience no symptoms throughout the course of infection, and pre-symptomatic individuals become infectious days before they report symptoms. Transmission of SARS-CoV-2 from individuals without symptoms contributes to pandemic spread, but the extent of transmission from persistently asymptomatic individuals remains unknown. We describe three methodological issues that hinder attempts to estimate this proportion. First, incomplete symptom assessment probably overestimates the asymptomatic fraction. Second, studies with inadequate follow-up misclassify pre-symptomatic individuals. Third, serological studies might identify people with previously unrecognised infection, but reliance on poorly defined antibody responses and retrospective symptom assessment might result in misclassification. We provide recommendations regarding definitions, detection, documentation, and follow-up to improve the identification and evaluation of people with persistently asymptomatic SARS-CoV-2 infection and their contacts. Accurate characterisation of the persistently asymptomatic fraction of infected individuals might shed light on COVID-19 pathogenesis and transmission dynamics, and inform public health responses.

Identifiants

DOI: 10.1016/S1473-3099(20)30837-9 PMID: 33301725 PMC: PMC7834404
pubmed: 33301725
pii: S1473-3099(20)30837-9
doi: 10.1016/S1473-3099(20)30837-9
pmc: PMC7834404
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

e163-e169

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

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Auteurs

Eric A Meyerowitz (EA)

Division of Infectious Diseases, Department of Medicine, Montefiore Medical Center, New York, NY, USA. Electronic address: emeyerowit@montefiore.org.

Aaron Richterman (A)

Division of Infectious Diseases, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

Isaac I Bogoch (II)

Division of Infectious Diseases, Toronto General Hospital, University of Toronto, Toronto, ON, Canada.

Nicola Low (N)

Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.

Muge Cevik (M)

Division of Infection and Global Health Research, School of Medicine, University of St Andrews, St Andrews, UK.

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Classifications MeSH

questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladies asymptomatiques › Infections asymptomatiques › Towards an accurate and systematic...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Towards an accurate and systematic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Towards an accurate and systematic...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Épidémies de maladies › Épidémies › Pandémies › Towards an accurate and systematic...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Towards an accurate and systematic...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Towards an accurate and systematic...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Tests immunologiques › Tests sérologiques › Towards an accurate and systematic...