Association of exposure to manganese and fine motor skills in welders - Results from the WELDOX II study.

Brain / diagnostic imaging Case-Control Studies Humans Magnetic Resonance Imaging Manganese / toxicity Manganese Poisoning / complications Metal Workers Middle Aged Motor Skills / drug effects Neuroimaging Occupational Exposure / adverse effects
Globus pallidus MRI Metals Neurobehaviour Neurotoxicity Substantia nigra

Journal

Neurotoxicology
ISSN: 1872-9711
Titre abrégé: Neurotoxicology
Pays: Netherlands
ID NLM: 7905589

Informations de publication

Date de publication:
01 2021
Historique:
received: 13 01 2020
revised: 23 10 2020
accepted: 02 12 2020
pubmed: 11 12 2020
medline: 30 10 2021
entrez: 10 12 2020
Statut: ppublish

Résumé

The aim of this study was to evaluate the effect of exposure to manganese (Mn) on fine motor functions. A total of 48 welders and 30 unexposed workers as controls completed questionnaires, underwent blood examinations, and a motor test battery. The shift exposure of welders to respirable Mn was measured with personal samplers. For all subjects accumulations of Mn in the brain were assessed with T1-weighted magnetic resonance imaging. Welders showed normal motor functions on the Movement Disorder Society-Sponsored Revision of the Unified Parkinson Disease Rating Scale part III. Furthermore welders performed excellent on a steadiness test, showing better results than controls. However, welders were slightly slower than controls in motor tests. There was no association between fine motor test results and the relaxation rates R1 in globus pallidus and substantia nigra as MRI-based biomarkers to quantify Mn deposition in the brain.

Identifiants

DOI: 10.1016/j.neuro.2020.12.003 PMID: 33301826 PMC: PMC8793460
pubmed: 33301826
pii: S0161-813X(20)30210-2
doi: 10.1016/j.neuro.2020.12.003
pmc: PMC8793460
mid: NIHMS1657001
pii:
doi:

Substances chimiques

Manganese 42Z2K6ZL8P

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

137-145

Subventions

Organisme : NIEHS NIH HHS
ID : R01 ES020529
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

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Auteurs

Anne Lotz (A)

Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany. Electronic address: lotz@ipa-dguv.de.

Beate Pesch (B)

Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany. Electronic address: pesch@ipa-dguv.de.

Swaantje Casjens (S)

Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany. Electronic address: casjens@ipa-dguv.de.

Martin Lehnert (M)

Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany. Electronic address: lehnert@ipa-dguv.de.

Wolfgang Zschiesche (W)

Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany. Electronic address: zschiesche@ipa-dguv.de.

Dirk Taeger (D)

Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany. Electronic address: taeger@ipa-dguv.de.

Chien-Lin Yeh (CL)

School of Health Sciences, Purdue University, West Lafayette, IN, USA; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: cyeh4@mgh.harvard.edu.

Tobias Weiss (T)

Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany. Electronic address: weiss@ipa-dguv.de.

Tobias Schmidt-Wilcke (T)

Department of Neurology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany; Institute of Clinical Neuroscience and Medical Psychology, University Hospital Düsseldorf, Meerbusch, Germany. Electronic address: tobias-schmidt-wilcke@t-online.de.

Clara Quetscher (C)

Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany; Institute for Cognitive Neuroscience, Biopsychology, Ruhr University Bochum, Bochum, Germany. Electronic address: clara.quetscher@rub.de.

Stefan Gabriel (S)

Institute for Occupational Safety and Health of the German Social Accident Insurance (IFA), Sankt Augustin, Germany. Electronic address: stefan.gabriel@dguv.de.

Maria Angela Samis Zella (MAS)

Department of Neurology, St. Josef- Hospital, Katholische Kliniken Ruhrhalbinsel, Contilia Gruppe, Essen, Germany. Electronic address: maria.zella@rub.de.

Dirk Woitalla (D)

Department of Neurology, St. Josef- Hospital, Katholische Kliniken Ruhrhalbinsel, Contilia Gruppe, Essen, Germany; Department of Neurology, Sankt Josef Hospital, Bochum, Germany. Electronic address: d.woitalla@contilia.de.

Ulrike Dydak (U)

School of Health Sciences, Purdue University, West Lafayette, IN, USA; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: udydak@purdue.edu.

Christoph van Thriel (C)

Leibniz Research Centre for Working Environment and Human Factors (IfADo), Dortmund, Germany. Electronic address: thriel@ifado.de.

Thomas Brüning (T)

Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany. Electronic address: bruening@ipa-dguv.de.

Thomas Behrens (T)

Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany. Electronic address: behrens@ipa-dguv.de.

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Classifications MeSH

questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Association of exposure to manganese and fine...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Association of exposure to manganese and fine...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Association of exposure to manganese and fine...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Association of exposure to manganese and fine...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Manganèse › Association of exposure to manganese and fine...
questionsmedicales.fr › Troubles dus à des produits chimiques › Intoxication › Empoisonnement aux métaux lourds › Intoxication au manganèse › Association of exposure to manganese and fine...
questionsmedicales.fr › Personnes › Groupes professionnels › Ouvriers métallurgistes › Association of exposure to manganese and fine...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Association of exposure to manganese and fine...
questionsmedicales.fr › Phénomènes psychologiques › Aptitudes motrices › Association of exposure to manganese and fine...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Association of exposure to manganese and fine...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Exposition environnementale › Exposition professionnelle › Association of exposure to manganese and fine...