Extracellular vesicles released from irradiated neonatal mouse cheek tissue increased cell survival after radiation.
Animals
Animals, Newborn
Cell Survival
/ radiation effects
Cheek
/ physiology
Colony-Forming Units Assay
DNA Repair
/ radiation effects
Dose-Response Relationship, Radiation
Extracellular Vesicles
/ metabolism
Female
Fibroblasts
/ radiation effects
Hair
/ growth & development
Male
Skin
/ radiation effects
X-Rays
animal model
extracellular vesicles
radiation protection
skin tissue
Journal
Journal of radiation research
ISSN: 1349-9157
Titre abrégé: J Radiat Res
Pays: England
ID NLM: 0376611
Informations de publication
Date de publication:
01 Jan 2021
01 Jan 2021
Historique:
received:
28
07
2020
revised:
17
09
2020
accepted:
09
10
2020
pubmed:
11
12
2020
medline:
29
9
2021
entrez:
10
12
2020
Statut:
ppublish
Résumé
Alopecia is one of the common symptoms after high-dose radiation exposure. In our experiments, neonatal mice that received 7 Gy X-ray exhibited defects in overall hair growth, except for their cheeks. This phenomenon might suggest that some substances were secreted and prevented hair follicle loss in the infant tissues around their cheeks after radiation damage. In this study, we focused on exosome-like vesicles (ELV) secreted from cheek skin tissues and back skin tissues, as control, and examined their radiation protective effects on mouse fibroblast cell lines. We observed that ELV from irradiated cheek skin showed protective effects from radiation. Our results suggest that ELV from radiation-exposed cheek skin tissue is one of the secreted factors that prevent hair follicle loss after high-dose radiation.
Identifiants
pubmed: 33302296
pii: 6030104
doi: 10.1093/jrr/rraa106
pmc: PMC7779349
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
73-78Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology.
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