Fungi.guru: Comparative genomic and transcriptomic resource for the fungi kingdom.
Co-expression
Database
Expression
Fungi
Gene function
Metabolism
Journal
Computational and structural biotechnology journal
ISSN: 2001-0370
Titre abrégé: Comput Struct Biotechnol J
Pays: Netherlands
ID NLM: 101585369
Informations de publication
Date de publication:
2020
2020
Historique:
received:
05
10
2020
revised:
10
11
2020
accepted:
10
11
2020
entrez:
11
12
2020
pubmed:
12
12
2020
medline:
12
12
2020
Statut:
epublish
Résumé
The fungi kingdom is composed of eukaryotic heterotrophs, which are responsible for balancing the ecosystem and play a major role as decomposers. They also produce a vast diversity of secondary metabolites, which have antibiotic or pharmacological properties. However, our lack of knowledge of gene function in fungi precludes us from tailoring them to our needs and tapping into their metabolic diversity. To help remedy this, we gathered genomic and gene expression data of 19 most widely-researched fungi to build an online tool, fungi.guru, which contains tools for cross-species identification of conserved pathways, functional gene modules, and gene families. We exemplify how our tool can elucidate the molecular function, biological process and cellular component of genes involved in various biological processes, by identifying a secondary metabolite pathway producing gliotoxin in
Identifiants
pubmed: 33304470
doi: 10.1016/j.csbj.2020.11.019
pii: S2001-0370(20)30486-4
pmc: PMC7718472
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3788-3795Informations de copyright
© 2020 The Author(s).
Déclaration de conflit d'intérêts
None of the authors have any competing interests. The data is available from www.fungi.guru and from the supplemental material.
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