Hypoxia and extracellular vesicles: A review on methods, vesicular cargo and functions.
cancer
exosomes
hypoxia
infarction
intercellular communication
mesenchymal stem cells
microRNA
Journal
Journal of extracellular vesicles
ISSN: 2001-3078
Titre abrégé: J Extracell Vesicles
Pays: United States
ID NLM: 101610479
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
04
06
2020
revised:
14
09
2020
accepted:
27
09
2020
entrez:
11
12
2020
pubmed:
12
12
2020
medline:
12
12
2020
Statut:
ppublish
Résumé
Hypoxia is an essential hallmark of several serious diseases such as cardiovascular and metabolic disorders and cancer. A decline in the tissue oxygen level induces hypoxic responses in cells which strive to adapt to the changed conditions. A failure to adapt to prolonged or severe hypoxia can trigger cell death. While some cell types, such as neurons, are highly vulnerable to hypoxia, cancer cells take advantage of a hypoxic environment to undergo tumour growth, angiogenesis and metastasis. Hypoxia-induced processes trigger complex intercellular communication and there are now indications that extracellular vesicles (EVs) play a fundamental role in these processes. Recent developments in EV isolation and characterization methodology have increased the awareness of the importance of EV purity in functional and cargo studies. Cell death, a hallmark of severe hypoxia, is a known source of intracellular contaminants in isolated EVs. In this review, methodological aspects of studies investigating hypoxia-induced EVs are critically evaluated. Key concerns and gaps in the current knowledge are highlighted and future directions for studies are set. To accelerate and advance research, an in-depth analysis of the functions and cargo of hypoxic EVs, compared to normoxic EVs, is provided with the focus on the altered microRNA contents of the EVs.
Identifiants
pubmed: 33304471
doi: 10.1002/jev2.12002
pii: JEV212002
pmc: PMC7710128
doi:
Substances chimiques
Circulating MicroRNA
0
RNA, Neoplasm
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Pagination
e12002Informations de copyright
© 2020 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles.
Déclaration de conflit d'intérêts
The authors report no conflict of interest.
Références
J Biosci. 2017 Sep;42(3):491-499
pubmed: 29358562
PLoS One. 2013 Dec 20;8(12):e83620
pubmed: 24376725
Blood. 2014 Dec 11;124(25):3748-57
pubmed: 25320245
J Extracell Vesicles. 2018 Dec 28;8(1):1560809
pubmed: 30651940
Cell Rep. 2016 Oct 11;17(3):799-808
pubmed: 27732855
Oncotarget. 2015 Sep 8;6(26):22836-56
pubmed: 26087400
Oncotarget. 2017 Feb 7;8(6):9899-9910
pubmed: 28038441
J Neurooncol. 2017 Oct;135(1):37-46
pubmed: 28948499
Oncogene. 2019 Apr;38(15):2830-2843
pubmed: 30546089
J Extracell Vesicles. 2012 Apr 16;1:
pubmed: 24009886
Nat Med. 2003 Jun;9(6):677-84
pubmed: 12778166
J Biol Chem. 2019 Aug 2;294(31):11665-11674
pubmed: 31217281
Sci Rep. 2017 Nov 10;7(1):15297
pubmed: 29127410
Oncogene. 2018 Aug;37(31):4239-4259
pubmed: 29713056
Am J Physiol Lung Cell Mol Physiol. 2010 Dec;299(6):L861-71
pubmed: 20693317
J Cell Biochem. 2017 Feb;118(2):252-262
pubmed: 27302189
Sci Rep. 2018 Jul 17;8(1):10813
pubmed: 30018314
J Cell Physiol. 2018 Apr;233(4):3498-3514
pubmed: 28929578
Cancer Res. 2016 Apr 1;76(7):1770-80
pubmed: 26992424
J Neurochem. 2009 Feb;108(4):1045-56
pubmed: 19196431
Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):E3234-42
pubmed: 24938788
Respir Res. 2016 Sep 05;17(1):110
pubmed: 27596748
Blood. 2004 Nov 1;104(9):2761-6
pubmed: 15242875
J Mol Med (Berl). 2016 Jun;94(6):711-24
pubmed: 26857375
Oncol Res. 2017 May 24;25(5):651-661
pubmed: 27712599
J Extracell Vesicles. 2019 Nov 29;9(1):1697028
pubmed: 31839906
Oncogene. 2017 Aug 24;36(34):4929-4942
pubmed: 28436951
IUBMB Life. 2020 Jul;72(7):1286-1305
pubmed: 32196941
Nat Cell Biol. 2011 Apr;13(4):423-33
pubmed: 21423178
J Cell Sci. 2012 Nov 1;125(Pt 21):5168-76
pubmed: 22946054
Mol Cancer. 2017 Aug 25;16(1):143
pubmed: 28841829
J Extracell Vesicles. 2019 Nov 20;9(1):1692401
pubmed: 31807236
Mol Cell Biochem. 2017 Jul;431(1-2):187-195
pubmed: 28283792
Circ Res. 2015 Jan 16;116(2):255-63
pubmed: 25344555
Eur Respir Rev. 2018 Jan 24;27(147):
pubmed: 29367408
Exp Cell Res. 2017 Feb 1;351(1):74-81
pubmed: 28043832
J Clin Invest. 2014 May;124(5):2136-46
pubmed: 24743145
J Extracell Vesicles. 2015 Dec 23;4:29509
pubmed: 26700615
Cancer Cell. 2017 Nov 13;32(5):669-683.e5
pubmed: 29136509
Cancers (Basel). 2020 Mar 14;12(3):
pubmed: 32183388
Int J Endocrinol. 2018 Apr 10;2018:6872635
pubmed: 29849622
Adv Biol Regul. 2015 Jan;57:24-41
pubmed: 25465297
J Immunol. 2009 Mar 15;182(6):3510-21
pubmed: 19265129
Oncoimmunology. 2015 Jun 24;5(4):e1062968
pubmed: 27141372
Nature. 2008 Jun 5;453(7196):807-11
pubmed: 18432192
Adv Drug Deliv Rev. 2015 Jun 29;87:3-14
pubmed: 25979468
Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7312-7
pubmed: 23589885
J Extracell Vesicles. 2014 Dec 22;3:26913
pubmed: 25536934
Nat Cell Biol. 2018 Mar;20(3):332-343
pubmed: 29459780
Nitric Oxide. 2017 Feb 28;63:1-12
pubmed: 28017872
Cancer Cell. 2014 Nov 10;26(5):605-22
pubmed: 25517747
J Extracell Vesicles. 2015 Jun 19;4:27522
pubmed: 26095380
Artif Cells Nanomed Biotechnol. 2018 Dec;46(8):1659-1670
pubmed: 29141446
Nat Methods. 2017 Feb 28;14(3):228-232
pubmed: 28245209
J Extracell Vesicles. 2016 Feb 15;5:29497
pubmed: 26895490
Acta Diabetol. 2014 Oct;51(5):823-31
pubmed: 24981880
Curr Protoc Cell Biol. 2006 Apr;Chapter 3:Unit 3.22
pubmed: 18228490
Nat Commun. 2013;4:2980
pubmed: 24356509
Biochem Biophys Res Commun. 2018 Feb 26;497(1):305-312
pubmed: 29428734
Nat Rev Clin Oncol. 2012 Apr 24;9(7):378-90
pubmed: 22525710
Sci Rep. 2016 Mar 02;6:22519
pubmed: 26931825
J Proteome Res. 2017 Aug 4;16(8):2836-2847
pubmed: 28641008
J Mol Cell Cardiol. 2012 Dec;53(6):848-57
pubmed: 23085511
Dig Dis Sci. 2019 Mar;64(3):792-802
pubmed: 30465177
Cell Death Dis. 2018 Mar 7;9(3):382
pubmed: 29515112
Front Mol Neurosci. 2019 Aug 28;12:200
pubmed: 31555088
Biochim Biophys Acta. 2013 Jul;1831(7):1302-9
pubmed: 24046871
BMC Cell Biol. 2016 Jun 23;17(1):25
pubmed: 27338159
Mol Ther. 2018 Feb 7;26(2):568-581
pubmed: 29292163
Int J Clin Exp Med. 2015 Mar 15;8(3):3825-32
pubmed: 26064280
J Appl Physiol (1985). 2000 Apr;88(4):1474-80
pubmed: 10749844
Hepatology. 2018 Mar;67(3):1056-1070
pubmed: 29059701
Nat Rev Mol Cell Biol. 2018 Apr;19(4):213-228
pubmed: 29339798
Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13147-52
pubmed: 21788507
Nat Commun. 2019 Sep 27;10(1):4397
pubmed: 31562301
J Biol Chem. 2013 Nov 29;288(48):34343-51
pubmed: 24133215
J Neurosci Res. 2017 Oct;95(10):2059-2070
pubmed: 28186348
PLoS One. 2014 Feb 18;9(2):e88685
pubmed: 24558412
Stem Cells Dev. 2018 Apr 1;27(7):456-465
pubmed: 29415626
Antioxid Redox Signal. 2014 Sep 10;21(8):1202-19
pubmed: 24053126
Front Cardiovasc Med. 2018 Oct 25;5:152
pubmed: 30410918
Stroke. 1994 Sep;25(9):1794-8
pubmed: 7521076
Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14888-93
pubmed: 25267620
Kidney Blood Press Res. 2012;35(3):182-91
pubmed: 22123256
J Immunol Methods. 2004 Nov;294(1-2):15-22
pubmed: 15604012
Oncol Rep. 2015 Jul;34(1):391-8
pubmed: 25955218
Sci Rep. 2016 Jun 16;6:28176
pubmed: 27307030
Biochem Biophys Res Commun. 2018 Jul 20;502(3):324-331
pubmed: 29787762
Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E968-77
pubmed: 26858453
Hypoxia (Auckl). 2015 Dec 11;3:83-92
pubmed: 27774485
Genes Dev. 2007 Oct 15;21(20):2644-58
pubmed: 17938244
Sci Signal. 2009 Dec 08;2(100):ra81
pubmed: 19996457
J Extracell Vesicles. 2019 Apr 26;8(1):1608786
pubmed: 31069027
Int J Mol Sci. 2017 Mar 28;18(4):
pubmed: 28350318
Br J Cancer. 2013 Feb 19;108(3):479-85
pubmed: 23299535
J Cell Biochem. 2018 May;119(5):4150-4160
pubmed: 29243842
Theranostics. 2018 Nov 29;8(22):6163-6177
pubmed: 30613290
J Extracell Vesicles. 2018 Nov 23;7(1):1535750
pubmed: 30637094
J Cell Mol Med. 2016 Feb;20(2):342-50
pubmed: 26612622
Mol Nutr Food Res. 2018 Mar;62(5):
pubmed: 29292863
Mol Carcinog. 2015 Jul;54(7):554-65
pubmed: 24347249
Neuroreport. 2019 Aug 14;30(12):834-841
pubmed: 31283710
Oncogene. 2018 Jul;37(28):3806-3821
pubmed: 29636548
Cancer Lett. 2018 Oct 28;435:80-91
pubmed: 30098399
Cell Mol Life Sci. 2018 Aug;75(15):2873-2886
pubmed: 29441425
J Neurooncol. 2019 Sep;144(3):477-488
pubmed: 31414377
J Exp Clin Cancer Res. 2019 Feb 8;38(1):62
pubmed: 30736829
Mol Cell. 2009 Sep 24;35(6):856-67
pubmed: 19782034
Immunity. 2019 Mar 19;50(3):738-750.e7
pubmed: 30770248
Cancer Res. 2018 Aug 15;78(16):4586-4598
pubmed: 29880482
Circ Res. 2016 Mar 18;118(6):970-83
pubmed: 26838793
J Extracell Vesicles. 2018 Dec 18;8(1):1555410
pubmed: 30574280
Nat Cell Biol. 2016 Apr;18(4):356-65
pubmed: 27027486
Stroke. 2016 Feb;47(2):561-9
pubmed: 26742797
Mol Cell Biol. 2002 Oct;22(20):7004-14
pubmed: 12242281
Int J Biochem Cell Biol. 2016 May;74:152-60
pubmed: 26923291
Cell Mol Neurobiol. 2016 Apr;36(3):301-12
pubmed: 27053351
FASEB J. 2018 Feb;32(2):654-668
pubmed: 28970251
J Extracell Vesicles. 2020 Jul 14;9(1):1791450
pubmed: 32944179
BMC Cancer. 2012 Sep 24;12:421
pubmed: 22998595
Microcirculation. 2015 Nov;22(8):711-23
pubmed: 26243428
PLoS One. 2013 Nov 11;8(11):e79636
pubmed: 24244532
Cell. 2004 Jan 23;116(2):281-97
pubmed: 14744438
Front Endocrinol (Lausanne). 2015 Apr 24;6:55
pubmed: 25964776
J Cell Biol. 2015 Mar 16;208(6):821-38
pubmed: 25753039
Med Sci Monit. 2018 Sep 05;24:6187-6199
pubmed: 30183690
Circulation. 2014 Sep 9;130(11):902-9
pubmed: 24982127
Exp Mol Med. 2019 Jun 20;51(6):1-13
pubmed: 31221962
Bioengineering (Basel). 2019 Jan 16;6(1):
pubmed: 30654439
Int J Biol Sci. 2019 May 7;15(6):1161-1176
pubmed: 31223277
Biomed Res Int. 2018 Jan 30;2018:8545347
pubmed: 29662902
J Biol Chem. 2011 Apr 8;286(14):12524-32
pubmed: 21296882
Cell Physiol Biochem. 2019;52(6):1463-1483
pubmed: 31099507
Cell Prolif. 2017 Feb;50(1):
pubmed: 27667148
Cell Signal. 2010 Apr;22(4):610-8
pubmed: 19932170
Mol Cancer. 2019 Mar 13;18(1):40
pubmed: 30866952
Yonsei Med J. 2018 Aug;59(6):736-745
pubmed: 29978610
Biomaterials. 2018 Jan;150:137-149
pubmed: 29040874
PLoS One. 2013 Jul 08;8(7):e68451
pubmed: 23861904
Nat Rev Immunol. 2007 Jun;7(6):454-65
pubmed: 17525754
Int Rev Cell Mol Biol. 2012;298:229-317
pubmed: 22878108
Oncol Rep. 2017 Jul;38(1):522-528
pubmed: 28586039