Hyaluronic acid in viscous malignant mesothelioma pleural effusion.
Hyaluronic acid
hyaluronidase
malignant pleural effusion
mesothelioma
viscosity
Journal
Respirology case reports
ISSN: 2051-3380
Titre abrégé: Respirol Case Rep
Pays: United States
ID NLM: 101631052
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
18
09
2020
revised:
03
11
2020
accepted:
15
11
2020
entrez:
11
12
2020
pubmed:
12
12
2020
medline:
12
12
2020
Statut:
epublish
Résumé
Malignant pleural effusion (MPE) is common with mesothelioma. We report two cases of extraordinarily viscous MPEs associated with mesothelioma. The viscosity prohibited spontaneous gravity-dependent drainage via indwelling pleural catheters. Our ex vivo experiments found very high hyaluronic acid (HA) content within the fluid. Treatment of the fluid with hyaluronidase, but not with deoxyribonucleases, significantly reduced fluid viscosity. The results provide proof that HA can contribute to high viscosity of pleural fluid in mesothelioma. Research into strategies of counteracting HA properties in the management of MPEs may provide further insight.
Identifiants
pubmed: 33304592
doi: 10.1002/rcr2.694
pii: RCR2694
pmc: PMC7715921
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e00694Informations de copyright
© 2020 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology.
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