Water-Soluble Vitamin Levels and Supplementation in Chronic Online Hemodiafiltration Patients.
clearance
hemodiafiltration
hemodialysis
vitamin B
vitamin C
Journal
Kidney international reports
ISSN: 2468-0249
Titre abrégé: Kidney Int Rep
Pays: United States
ID NLM: 101684752
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
10
03
2020
revised:
03
09
2020
accepted:
08
09
2020
entrez:
11
12
2020
pubmed:
12
12
2020
medline:
12
12
2020
Statut:
epublish
Résumé
Supplementation of water-soluble vitamins is a common practice in hemodialysis patients, but dosages are largely based on conventional hemodialysis techniques. The aim of this study was to assess the status of water-soluble vitamins in patients on hemodiafiltration (HDF), and attempt to determine optimal dose of vitamin supplements. This monocentric study included 40 patients on thrice-weekly chronic HDF. At baseline, all patients received 2 tablets of Dialvit containing B and C vitamins after each dialysis session. Predialysis samples of B and C vitamins were measured in both blood ( At baseline, B-vitamin levels were high with, respectively, 0.4%, 10.0%, and 89.6% of patients in the low, normal, and high reference range. For vitamin C, most patients were in the normal range (5.0%, 82.5%, and 12.5% in low, normal, and high reference range). Three months after dose reduction, B vitamin levels decreased but stayed mostly at or above the normal range (1.4%, 25.7%, 72.9% in low, normal, and high reference range). Three patients (12.5%) developed vitamin C deficiency on low-dose substititon. This study shows that the levels of most vitamins are above the normal range in patients on HDF receiving a classic dose of vitamin supplements, vitamin C excepted. Our study suggests that the classic dose of postdialysis vitamin B supplements may be reduced.
Identifiants
pubmed: 33305108
doi: 10.1016/j.ekir.2020.09.009
pii: S2468-0249(20)31524-2
pmc: PMC7710883
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2160-2167Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 International Society of Nephrology. Published by Elsevier Inc.
Références
Intensive Care Med. 1999 Jun;25(6):594-8
pubmed: 10416911
Nephron Clin Pract. 2011;118 Suppl 1:c153-64
pubmed: 21555894
Nephrol Dial Transplant. 1999 Jul;14(7):1679-86
pubmed: 10435876
Hemodial Int. 2011 Oct;15(4):509-14
pubmed: 22111819
Nephrol Dial Transplant. 2002 Mar;17(3):422-7
pubmed: 11865087
Nephrol Dial Transplant. 2007 May;22 Suppl 2:ii45-87
pubmed: 17507426
Kidney Int. 2013 Sep;84(3):622-3
pubmed: 23989362
J Chronic Dis. 1987;40(5):373-83
pubmed: 3558716
J Ren Care. 2009 Dec;35(4):201-4
pubmed: 19909413
Semin Dial. 2016 Jan-Feb;29(1):39-48
pubmed: 26384581
Eur J Nutr. 2017 Feb;56(1):283-293
pubmed: 26502280
Kidney Int. 1993 Jun;43(6):1319-28
pubmed: 8315945
Kidney Int. 1997 Aug;52(2):530-7
pubmed: 9264013
J Am Soc Nephrol. 1996 May;7(5):780-5
pubmed: 8738814
Nephrol Dial Transplant. 2010 Jan;25(1):212-8
pubmed: 19755476
J Am Soc Nephrol. 1993 Nov;4(5):1205-13
pubmed: 8305648
Kidney Int. 2013 Jun;83(6):979-81
pubmed: 23575565
Am J Kidney Dis. 2004 Nov;44(5 Suppl 2):61-7
pubmed: 15486876
Int J Vitam Nutr Res. 1999 Sep;69(5):362-6
pubmed: 10526782
Scand J Urol Nephrol. 2008;42(1):74-80
pubmed: 18210337
Med J Aust. 1989 Feb 6;150(3):130-3
pubmed: 2716581
Semin Dial. 2013 Sep-Oct;26(5):546-67
pubmed: 23859229