Health-Related Quality of Life in People Across the Spectrum of CKD.
EuroQoL-5D3L
chronic kidney disease
domain-specific QoL
quality of life
Journal
Kidney international reports
ISSN: 2468-0249
Titre abrégé: Kidney Int Rep
Pays: United States
ID NLM: 101684752
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
05
09
2020
accepted:
08
09
2020
entrez:
11
12
2020
pubmed:
12
12
2020
medline:
12
12
2020
Statut:
epublish
Résumé
People with chronic kidney disease (CKD) experience reduced quality of life (QoL) because of the high symptom and treatment burden. Limited data exist on the factors associated with overall and domain-specific QoL across all CKD stages. Using data from a prospective, multinational study (Australia, New Zealand, Canada, and Spain) in 1696 participants with CKD, we measured overall and domain-specific QoL (pain, self-care, activity, mobility, anxiety/depression) using the EuroQoL, 5 dimension, 3 level. Multivariable linear regression and logistic modeling were used to determine factors associated with overall and domain-specific QoL. QoL for patients with CKD stages 3 to 5 (n = 787; mean, 0.81; SD, 0.20) was higher than in patients on dialysis (n = 415; mean, 0.76; SD, 0.24) but lower than in kidney transplant recipients (n = 494; mean, 0.84; SD, 0.21). Factors associated with reduced overall QoL (β [95% confidence intervals]) included being on dialysis (compared with CKD stages 3-5: -0.06 [-0.08 to -0.03]), female sex (-0.03 [-0.05 to -0.006]), lower educational attainment (- 0.04 [-0.06 to -0.02), lacking a partner (-0.04 [-0.06 to -0.02]), having diabetes (-0.05 [-0.07 to -0.02]), history of stroke (-0.09 [-0.13 to -0.05]), cardiovascular disease (-0.06 [-0.08 to -0.03]), and cancer (-0.03 [-0.06 to -0.009]). Pain (43%) and anxiety/depression (30%) were the most commonly affected domains, with dialysis patients reporting decrements in all 5 domains. Predictors for domain-specific QoL included being on dialysis, presence of comorbidities, lower education, female sex, and lack of a partner. Being on dialysis, women with CKD, those with multiple comorbidities, lack of a partner, and lower educational attainment were associated with lower QoL across all stages of CKD.
Identifiants
pubmed: 33305120
doi: 10.1016/j.ekir.2020.09.028
pii: S2468-0249(20)31544-8
pmc: PMC7710842
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2264-2274Informations de copyright
© 2020 International Society of Nephrology. Published by Elsevier Inc.
Références
Am J Kidney Dis. 2003 Mar;41(3):596-604
pubmed: 12612983
Demography. 1990 May;27(2):233-50
pubmed: 2332088
Am J Kidney Dis. 2016 Sep;68(3):353-70
pubmed: 27020884
Nephrol Dial Transplant. 2015 Nov;30(11):1885-92
pubmed: 26056174
BMC Nephrol. 2008 Jan 31;9:2
pubmed: 18237373
Psychooncology. 2004 Jun;13(6):408-28
pubmed: 15188447
BMC Nephrol. 2019 Mar 29;20(1):108
pubmed: 30922246
BMC Nephrol. 2012 Apr 24;13:19
pubmed: 22530944
Prostate Cancer Prostatic Dis. 2009;12(3):253-8
pubmed: 19172158
Soc Psychiatry Psychiatr Epidemiol. 2017 Jun;52(6):627-638
pubmed: 28528389
J Res Med Sci. 2011 May;16(5):666-73
pubmed: 22091290
J Med Internet Res. 2016 Jan 28;18(1):e18
pubmed: 26822073
Am J Kidney Dis. 2016 Jun;67(6):851-60
pubmed: 26706255
PLoS Med. 2012;9(9):e1001307
pubmed: 22984353
N Engl J Med. 2004 Sep 23;351(13):1296-305
pubmed: 15385656
PLoS One. 2019 Jul 18;14(7):e0219663
pubmed: 31318898
Soc Sci Med. 2009 Oct;69(8):1220-7
pubmed: 19699572
Semin Dial. 2014 Mar;27(2):188-204
pubmed: 24517512
Clin Exp Nephrol. 2010 Aug;14(4):340-8
pubmed: 20567874
Clin J Am Soc Nephrol. 2009 Aug;4(8):1293-301
pubmed: 19643926
Arch Intern Med. 2009 Oct 12;169(18):1692-7
pubmed: 19822826
Health Qual Life Outcomes. 2016 Sep 20;14(1):133
pubmed: 27644755
Qual Life Res. 2014 Oct;23(8):2375-81
pubmed: 24676898
Clin J Am Soc Nephrol. 2016 Dec 7;11(12):2250-2255
pubmed: 27660303
BMC Womens Health. 2015 Nov 21;15:105
pubmed: 26590558
Clin J Am Soc Nephrol. 2019 Jun 7;14(6):917-931
pubmed: 30833302
Nephrol Dial Transplant. 2001 Jul;16(7):1387-94
pubmed: 11427630
BMC Public Health. 2011 Jun 29;11:516
pubmed: 21714917
Nephrology (Carlton). 2012 Jan;17(1):32-41
pubmed: 22017753
Soc Sci Med. 2008 Dec;67(12):2072-8
pubmed: 18952344
Ann Intern Med. 2009 May 5;150(9):604-12
pubmed: 19414839
Qual Life Res. 2019 Aug;28(8):2081-2090
pubmed: 30937731
Transplant Proc. 2006 Mar;38(2):419-21
pubmed: 16549136
Nephrol Dial Transplant. 2018 Sep 1;33(9):1545-1558
pubmed: 29165627
J Am Soc Nephrol. 2019 Jun;30(6):1061-1072
pubmed: 31040191
Kidney Int. 2005 Mar;67(3):1093-104
pubmed: 15698450
Health Policy. 1990 Dec;16(3):199-208
pubmed: 10109801
Health Qual Life Outcomes. 2007 Dec 21;5:70
pubmed: 18154669
Br J Anaesth. 2013 Jul;111(1):52-8
pubmed: 23794645
Med Care. 2005 Nov;43(11):1078-86
pubmed: 16224300
Value Health. 2011 Sep-Oct;14(6):928-36
pubmed: 21914515
PLoS One. 2018 Nov 26;13(11):e0207960
pubmed: 30475893
Health Qual Life Outcomes. 2014 Aug 08;12:109
pubmed: 25104276