MicroRNA-125b-5p Regulates Hepatocyte Proliferation During the Termination Phase of Liver Regeneration.
Journal
Hepatology communications
ISSN: 2471-254X
Titre abrégé: Hepatol Commun
Pays: United States
ID NLM: 101695860
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
20
05
2020
revised:
09
07
2020
accepted:
22
07
2020
entrez:
11
12
2020
pubmed:
12
12
2020
medline:
12
12
2020
Statut:
epublish
Résumé
The ability of the liver to regenerate and restore mass limits the increasing mortality rate due to life-threatening liver diseases. Successful liver regeneration is accomplished in multiple stages, of which the priming and proliferation phases are well studied. However, the regulatory pathways, specifically microRNA (miRNA)-mediated posttranscriptional regulation, which prevent uncontrolled proliferation and mediate the termination of liver regeneration, are not well understood. We identified differentially regulated miRNAs during the termination phase after 2/3 partial hepatectomy (PH) in mice, which is a well-established mouse model of liver regeneration. We further evaluated the function of differentially regulated miRNAs in primary mouse hepatocytes by using mimics and inhibitors and
Identifiants
pubmed: 33305155
doi: 10.1002/hep4.1597
pii: HEP41597
pmc: PMC7706294
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1851-1863Informations de copyright
© 2020 The Authors. Hepatology Communications published by Wiley Periodicals LLC on behalf of the American Association for the Study of Liver Diseases.
Références
Leukemia. 2012 Sep;26(9):2011-8
pubmed: 22456625
Toxicol In Vitro. 2016 Oct;36:224-237
pubmed: 27530964
Hepatology. 2013 Mar;57(3):1055-67
pubmed: 23079745
Hepatology. 2013 Sep;58(3):1143-52
pubmed: 23526443
Hepatology. 2009 Sep;50(3):844-51
pubmed: 19575460
Mol Endocrinol. 2008 Jan;22(1):78-90
pubmed: 17885207
J Hepatol. 2016 Feb;64(2):352-360
pubmed: 26456844
Haematologica. 2012 Nov;97(11):1713-21
pubmed: 22689670
PLoS One. 2014 Jul 07;9(7):e101386
pubmed: 24999631
Hepatology. 2010 Nov;52(5):1731-40
pubmed: 20827722
Cancer Res. 1986 May;46(5):2330-4
pubmed: 3008986
Acta Medica (Hradec Kralove). 2009;52(3):91-9
pubmed: 20073420
Oncogene. 2001 Jul 27;20(33):4457-65
pubmed: 11494141
EMBO Mol Med. 2010 Aug;2(8):294-305
pubmed: 20652897
Hepatology. 2019 Aug;70(2):666-681
pubmed: 30520062
Nature. 2010 Aug 12;466(7308):835-40
pubmed: 20703300
Eur Surg Res. 2012;48(3):139-53
pubmed: 22572792
Genes Dev. 2014 Apr 15;28(8):858-74
pubmed: 24736844
PLoS One. 2011;6(5):e20238
pubmed: 21655280
Nat Commun. 2016 Jun 23;7:11916
pubmed: 27336362
Hepatology. 2015 Jan;61(1):315-25
pubmed: 25043739
FEBS Lett. 2011 Mar 23;585(6):927-34
pubmed: 21354414
Cell. 2004 Apr 16;117(2):211-23
pubmed: 15084259
Br J Cancer. 2009 Oct 20;101(8):1433-43
pubmed: 19755996
Int J Biol Sci. 2015 Aug 21;11(10):1236-47
pubmed: 26327817
Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12169-74
pubmed: 25092309
Science. 2014 Jan 24;343(6169):416-9
pubmed: 24458641
Cereb Cortex. 2019 Mar 1;29(3):1006-1019
pubmed: 29385539
Hepatology. 2010 May;51(5):1735-43
pubmed: 20432256
J Clin Invest. 2012 Mar;122(3):1097-108
pubmed: 22326957
Hepatology. 2013 Jan;57(1):299-310
pubmed: 22821679
Nat Rev Gastroenterol Hepatol. 2013 Sep;10(9):542-52
pubmed: 23689081