Volumetric Modeling of Adrenal Gland Size in Primary Bilateral Macronodular Adrenocortical Hyperplasia.
ARMC5
Cushing syndrome
PBMAH
adrenal hyperplasia
steroids
volumetric
Journal
Journal of the Endocrine Society
ISSN: 2472-1972
Titre abrégé: J Endocr Soc
Pays: United States
ID NLM: 101697997
Informations de publication
Date de publication:
01 Jan 2021
01 Jan 2021
Historique:
received:
31
08
2020
entrez:
11
12
2020
pubmed:
12
12
2020
medline:
12
12
2020
Statut:
epublish
Résumé
Radiological characterization of adrenal size in primary bilateral macronodular adrenocortical hyperplasia (PBMAH) has not been previously investigated. We hypothesized that volumetric modeling of adrenal gland size may correlate with biochemical disease severity in patients with PBMAH. Secondary analysis of patients with concurrent primary aldosteronism (PA) was performed. A retrospective cross-sectional analysis of 44 patients with PBMAH was conducted from 2000 to 2019. Tertiary care clinical research center. Patients were diagnosed with PBMAH based upon clinical, genetic, radiographic and biochemical characteristics. Clinical, biochemical, and genetic data were obtained. Computed tomography scans were used to create volumetric models by manually contouring both adrenal glands in each slice using Vitrea Core Fx v6.3 software (Vital Images, Minnetonka, Minnesota). 17-hydroxycorticosteroids (17-OHS), A cohort of 44 patients with PBMAH was evaluated, with a mean age (±SD) of 53 ± 11.53. Eight patients met the diagnostic criteria for PA, of whom 6 (75%) were Black. In the Black cohort, total adrenal volumes positively correlated with midnight cortisol (R = 0.76, Volumetric modeling of adrenal gland size may associate with biochemical severity in patients with PBMAH, with particular utility in Black patients.
Identifiants
pubmed: 33305158
doi: 10.1210/jendso/bvaa162
pii: bvaa162
pmc: PMC7716656
doi:
Types de publication
Journal Article
Langues
eng
Pagination
bvaa162Informations de copyright
Published by Oxford University Press on behalf of the Endocrine Society 2020.
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