Deciphering the role of microRNAs in mustard gas-induced toxicity.
2-chloroethyl ethyl sulfide
microRNAs
nitrogen mustard
sulfur mustard
toxicity
Journal
Annals of the New York Academy of Sciences
ISSN: 1749-6632
Titre abrégé: Ann N Y Acad Sci
Pays: United States
ID NLM: 7506858
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
26
10
2020
received:
09
07
2020
accepted:
01
11
2020
pubmed:
12
12
2020
medline:
25
5
2021
entrez:
11
12
2020
Statut:
ppublish
Résumé
Mustard gas (sulfur mustard, SM), a highly vesicating chemical warfare agent, was first deployed in warfare in 1917 and recently during the Iraq-Iran war (1980s) and Syrian conflicts (2000s); however, the threat of exposure from stockpiles and old artillery shells still looms large. Whereas research has been long ongoing on SM-induced toxicity, delineating the precise molecular pathways is still an ongoing area of investigation; thus, it is important to attempt novel approaches to decipher these mechanisms and develop a detailed network of pathways associated with SM-induced toxicity. One such avenue is exploring the role of microRNAs (miRNAs) in SM-induced toxicity. Recent research on the regulatory role of miRNAs provides important results to fill in the gaps in SM toxicity-associated mechanisms. In addition, differentially expressed miRNAs can also be used as diagnostic markers to determine the extent of toxicity in exposed individuals. Thus, in our review, we have summarized the studies conducted so far in cellular and animal models, including human subjects, on the expression profiles and roles of miRNAs in SM- and/or SM analog-induced toxicity. Further detailed research in this area will guide us in devising preventive strategies, diagnostic tools, and therapeutic interventions against SM-induced toxicity.
Identifiants
pubmed: 33305460
doi: 10.1111/nyas.14539
pmc: PMC8211033
mid: NIHMS1644312
doi:
Substances chimiques
Chemical Warfare Agents
0
MicroRNAs
0
Mustard Gas
T8KEC9FH9P
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
25-41Subventions
Organisme : NIAMS NIH HHS
ID : R21 AR074929
Pays : United States
Organisme : NIAMS NIH HHS
ID : R21AR074929
Pays : United States
Informations de copyright
© 2020 New York Academy of Sciences.
Références
J Lipid Res. 2013 May;54(5):1174-81
pubmed: 23505318
Gene Regul Syst Bio. 2016 Apr 27;10(Suppl 1):11-7
pubmed: 27147820
Ann N Y Acad Sci. 2016 Jun;1374(1):184-92
pubmed: 27326543
Arch Toxicol. 2018 Dec;92(12):3443-3457
pubmed: 30155719
Chest. 1997 Sep;112(3):734-8
pubmed: 9315808
Ann N Y Acad Sci. 2020 Nov;1479(1):148-158
pubmed: 32602122
Ann N Y Acad Sci. 2016 Jun;1374(1):193-201
pubmed: 27327041
Inhal Toxicol. 2015;27(13):682-8
pubmed: 26525353
Am J Physiol Lung Cell Mol Physiol. 2008 Apr;294(4):L739-48
pubmed: 18245268
J Exp Clin Cancer Res. 2016 Nov 15;35(1):177
pubmed: 27846906
Oncogene. 2018 Apr;37(14):1926-1938
pubmed: 29367757
Nat Rev Mol Cell Biol. 2014 Sep;15(9):565-76
pubmed: 25118717
Int J Oncol. 2012 Jan;40(1):119-29
pubmed: 21879257
Cell Death Differ. 2013 Dec;20(12):1603-14
pubmed: 24212931
Exp Lung Res. 2012 Aug;38(6):286-94
pubmed: 22686440
Emerg Health Threats J. 2008;1:e7
pubmed: 22460216
Iran J Allergy Asthma Immunol. 2019 Jun 08;18(3):332-339
pubmed: 31522440
Urol J. 2019 Jun 17;16(3):267-273
pubmed: 30318571
Lung Cancer. 2011 Oct;74(1):41-7
pubmed: 21388703
Eur Rev Med Pharmacol Sci. 2018 Feb;22(4):1011-1019
pubmed: 29509249
Int Immunopharmacol. 2005 Aug;5(9):1479-85
pubmed: 15953574
Exp Hematol Oncol. 2018 May 2;7:10
pubmed: 29744254
J Appl Toxicol. 2006 Mar-Apr;26(2):126-31
pubmed: 16252256
Genome Res. 2009 Jan;19(1):92-105
pubmed: 18955434
Trends Biochem Sci. 2016 Oct;41(10):883-892
pubmed: 27597517
Genes Cancer. 2018 Jan;9(1-2):53-65
pubmed: 29725503
J Exp Med. 2010 Aug 2;207(8):1589-97
pubmed: 20643828
Eplasty. 2008 Jun 10;8:e32
pubmed: 18615149
Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10849-E10858
pubmed: 30373812
Circ Res. 2010 Sep 3;107(5):677-84
pubmed: 20595655
Inhal Toxicol. 2019 Jan;31(1):3-11
pubmed: 31010353
Int J Clin Exp Pathol. 2018 Dec 01;11(12):5901-5908
pubmed: 31949677
Oncol Lett. 2017 Aug;14(2):2552-2558
pubmed: 28789462
Cells. 2020 Jan 15;9(1):
pubmed: 31952362
Arch Toxicol. 2017 Mar;91(3):1143-1156
pubmed: 28032143
Cell Death Dis. 2017 Aug 24;8(8):e3010
pubmed: 28837140
BMB Rep. 2020 Feb;53(2):82-87
pubmed: 31072448
Toxicol Rep. 2020 Jan 13;7:198-199
pubmed: 32021809
Eur Rev Med Pharmacol Sci. 2018 Jan;22(1):40-45
pubmed: 29364469
Arch Toxicol. 2019 Jul;93(7):1881-1891
pubmed: 31069408
Mol Neurobiol. 2020 Feb;57(2):988-996
pubmed: 31654316
Cancer Sci. 2020 Feb;111(2):418-428
pubmed: 31799727
Caspian J Intern Med. 2019 Summer;10(3):241-264
pubmed: 31558985
Tumour Biol. 2016 Oct 8;:
pubmed: 27718128
Front Genet. 2013 Jun 28;4:119
pubmed: 23825476
Public Health. 2000 Jul;114(4):238-48
pubmed: 10962584
Int J Med Sci. 2018 Sep 7;15(13):1443-1448
pubmed: 30443163
Oncotarget. 2015 Apr 20;6(11):8474-90
pubmed: 25893379
Mol Cell Endocrinol. 2020 Jan 1;499:110603
pubmed: 31574295
Gene. 2019 Sep 25;714:143968
pubmed: 31323308
Diabetes. 2019 Mar;68(3):617-630
pubmed: 30523028
Oncol Lett. 2016 Dec;12(6):5023-5028
pubmed: 28105209
Cell Mol Life Sci. 2019 Feb;76(3):441-451
pubmed: 30374521
Chem Biol Interact. 2013 Dec 5;206(3):512-22
pubmed: 23816402
Int J Mol Med. 2017 Dec;40(6):1624-1630
pubmed: 29039606
J Exp Clin Cancer Res. 2018 Jan 30;37(1):15
pubmed: 29382357
Cell Death Dis. 2018 Jul 23;9(8):803
pubmed: 30038357
Int J Mol Sci. 2016 Oct 13;17(10):
pubmed: 27754357
Cutan Ocul Toxicol. 2013 Oct;32(4):304-24
pubmed: 23590683
Sci Rep. 2018 Sep 11;8(1):13596
pubmed: 30206364
J Cell Biochem. 2018 Nov;119(10):8643-8658
pubmed: 29953642
Oncogene. 2014 Feb 6;33(6):702-12
pubmed: 23416980
Development. 2013 May;140(9):1882-91
pubmed: 23571213
Mutat Res Genet Toxicol Environ Mutagen. 2016 Apr;800-801:12-21
pubmed: 27085470
Cell. 1993 Dec 3;75(5):843-54
pubmed: 8252621
Immunopharmacol Immunotoxicol. 2018 Aug;40(4):290-296
pubmed: 29676192
Toxicol Lett. 2012 Feb 25;209(1):1-10
pubmed: 22119920
Oncotarget. 2017 Aug 1;8(41):71292-71316
pubmed: 29050362
Wiley Interdiscip Rev Dev Biol. 2013 Jan-Feb;2(1):47-63
pubmed: 23799630
Toxicol Lett. 2016 Feb 26;244:88-94
pubmed: 26456178
Cell. 1993 Dec 3;75(5):855-62
pubmed: 8252622
Mol Neurobiol. 2016 Apr;53(3):2016-2028
pubmed: 25862375
Int J Mol Med. 2017 Oct;40(4):1047-1056
pubmed: 28902356
Cancer Res. 2011 May 15;71(10):3563-72
pubmed: 21471404
Toxicol Rep. 2017 Nov 13;4:634-636
pubmed: 29214146
J Recept Signal Transduct Res. 2015;35(6):634-9
pubmed: 26498464
Biomed Pharmacother. 2014 Oct;68(8):935-42
pubmed: 25451164
Front Endocrinol (Lausanne). 2018 Aug 03;9:402
pubmed: 30123182
Cell Oncol (Dordr). 2020 Apr;43(2):249-261
pubmed: 31884576
Chem Biol Interact. 2013 Dec 5;206(3):505-11
pubmed: 23933411
Mol Aspects Med. 2019 Dec;70:90-105
pubmed: 31703947
Toxicol Lett. 2016 Feb 26;244:44-48
pubmed: 26463895
Toxicol Appl Pharmacol. 2016 Aug 15;305:1-11
pubmed: 27212445
Oncol Lett. 2018 Jun;15(6):8269-8280
pubmed: 29844810
Cell J. 2015 Fall;17(3):494-501
pubmed: 26464821
J Cancer Res Clin Oncol. 2019 Jun;145(6):1635-1643
pubmed: 30923943
Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9667-72
pubmed: 17535905
Thorac Cancer. 2020 Mar;11(3):619-630
pubmed: 31962380
Interdiscip Toxicol. 2015 Dec;8(4):169-74
pubmed: 27486378
Chem Res Toxicol. 2010 Jun 21;23(6):1034-44
pubmed: 20469912
Oxid Med Cell Longev. 2017;2017:2398696
pubmed: 28593022
Mol Ther. 2020 Jan 8;28(1):142-156
pubmed: 31606324
Proc Am Thorac Soc. 2012 Jul;9(3):111-6
pubmed: 22802283
PLoS One. 2011;6(5):e20509
pubmed: 21637828
Toxicol Mech Methods. 2017 Jul;27(6):408-416
pubmed: 28413899
Oncol Rep. 2019 Nov;42(5):1957-1971
pubmed: 31432186
Cell Physiol Biochem. 2016;39(6):2186-2202
pubmed: 27802440
J Dermatol Case Rep. 2012 Sep 28;6(3):86-9
pubmed: 23091586
Antioxid Redox Signal. 2018 Feb 10;28(5):358-370
pubmed: 28683566
JCI Insight. 2016 Dec 8;1(20):e90301
pubmed: 27942594
Jpn J Clin Oncol. 2015 Aug;45(8):738-44
pubmed: 25917358
J Biol Chem. 2011 Jun 17;286(24):21401-12
pubmed: 21518763
Clin Toxicol (Phila). 2020 Jan;58(1):36-44
pubmed: 31072153
J Cell Biochem. 2020 Jan;121(1):70-80
pubmed: 31074095
Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6976-81
pubmed: 20308562
Cell Physiol Biochem. 2018;50(6):2176-2187
pubmed: 30415251
Ann Pharmacother. 2008 Feb;42(2):237-46
pubmed: 18212254
Sci Rep. 2017 Jan 23;7:41304
pubmed: 28112253
Cell Cycle. 2008 Oct;7(20):3143-8
pubmed: 18843198
Ageing Res Rev. 2017 May;35:350-363
pubmed: 27903442
Toxicol Lett. 2016 Feb 26;244:81-87
pubmed: 26383628
Toxicology. 2005 Oct 30;214(3):198-209
pubmed: 16084004
Free Radic Biol Med. 2019 Aug 1;139:1-15
pubmed: 31102709
Lasers Med Sci. 2020 Jun;35(4):833-839
pubmed: 31485783
Oncotarget. 2017 Jul 4;8(27):43897-43914
pubmed: 28159925
Oncotarget. 2016 Sep 13;7(37):60230-60244
pubmed: 27517626
Mol Cell Biol. 2011 Dec;31(23):4760-74
pubmed: 21969601
Cancer Metastasis Rev. 2018 Mar;37(1):17-32
pubmed: 29327093
Mol Metab. 2020 Jan;31:150-162
pubmed: 31918917
Mol Immunol. 2013 Dec;56(4):442-51
pubmed: 23911400
J Appl Toxicol. 2010 Oct;30(7):627-43
pubmed: 20836142
Cell Death Differ. 2010 Feb;17(2):209-14
pubmed: 19461655
Breast Cancer. 2017 Jul;24(4):521-527
pubmed: 28477068
Microcirculation. 2012 Apr;19(3):215-23
pubmed: 22171547
Front Immunol. 2019 Apr 17;10:799
pubmed: 31057539
Microrna. 2019;8(1):76-85
pubmed: 30147021
Sci Rep. 2019 May 6;9(1):6956
pubmed: 31061410
Bioinformation. 2017 Jun 30;13(6):209-213
pubmed: 28729764
Fundam Clin Pharmacol. 2005 Jun;19(3):297-315
pubmed: 15910653
Toxicol Lett. 2018 Sep 1;293:38-44
pubmed: 28823541
J Transl Med. 2019 Oct 22;17(1):347
pubmed: 31640738
Int J Prev Med. 2016 May 19;7:76
pubmed: 27280012
Pharmacol Rev. 1996 Jun;48(2):289-326
pubmed: 8804107
J Emerg Med. 1994 Mar-Apr;12(2):159-66
pubmed: 8207150
Proc Am Thorac Soc. 2008 Aug 15;5(6):703-6
pubmed: 18684721
Toxicol Lett. 2020 Jan;318:92-98
pubmed: 31678399
Oncol Lett. 2018 Apr;15(4):5611-5619
pubmed: 29552198
Cutan Ocul Toxicol. 2019 Mar;38(1):9-17
pubmed: 29969302
Oncol Lett. 2020 Mar;19(3):2326-2338
pubmed: 32194732
Inhal Toxicol. 2015;27(13):659-72
pubmed: 26446928
J Pharm Bioallied Sci. 2010 Jul;2(3):166-78
pubmed: 21829312
Eur J Dermatol. 2013 Apr 19;:
pubmed: 23608026
Toxicology. 2009 Sep 1;263(1):3-8
pubmed: 19482056
J Invest Dermatol. 2020 Feb;140(2):465-476.e11
pubmed: 31376385
Sci Rep. 2017 Aug 28;7(1):9655
pubmed: 28848235
EXCLI J. 2019 Jul 16;18:515-529
pubmed: 31423132
Inhal Toxicol. 2011 Jun;23(7):363-71
pubmed: 21639706
Cancer Cell. 2017 Apr 10;31(4):576-590.e8
pubmed: 28399412
Front Immunol. 2020 Feb 06;11:133
pubmed: 32117280
Cell Rep. 2019 Jun 18;27(12):3618-3628.e5
pubmed: 31216479
Cell. 2004 Jan 23;116(2):281-97
pubmed: 14744438
Oncogene. 2010 Jul 29;29(30):4297-306
pubmed: 20514023
J Exp Clin Cancer Res. 2019 Feb 4;38(1):53
pubmed: 30717802
Clin Exp Dermatol. 2006 Jan;31(1):1-5
pubmed: 16309468
CMAJ. 2017 Feb 27;189(8):E321-E322
pubmed: 28246228
Cytokine. 2012 Dec;60(3):741-8
pubmed: 22917968
Oncotarget. 2014 Feb 28;5(4):872-81
pubmed: 24657911
PLoS One. 2018 Mar 22;13(3):e0194530
pubmed: 29566027
J Pharmacol Exp Ther. 2011 Feb;336(2):450-9
pubmed: 20974699
Int J Cancer. 2017 May 15;140(10):2310-2320
pubmed: 28224609
J Biochem. 2020 Sep 1;168(3):203-211
pubmed: 32196088
Mol Cancer. 2015 Feb 13;14:37
pubmed: 25744894
Stem Cell Rev Rep. 2018 Jun;14(3):309-322
pubmed: 29541978
Arch Biochem Biophys. 2018 Aug 1;651:52-60
pubmed: 29802821
Oncotarget. 2018 Jan 23;9(11):10164-10174
pubmed: 29515800
World J Gastroenterol. 2016 Feb 21;22(7):2206-18
pubmed: 26900285
Int Arch Allergy Immunol. 2018;177(3):207-218
pubmed: 30048989