Brain plasticity dynamics during tactile Braille learning in sighted subjects: Multi-contrast MRI approach.
Brain plasticity
Intracortical myelin
Longitudinal design
Multimodal MRI
Quantitative MRI
Tactile Braille reading
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
15 02 2021
15 02 2021
Historique:
received:
16
06
2020
revised:
20
11
2020
accepted:
29
11
2020
pubmed:
12
12
2020
medline:
2
3
2021
entrez:
11
12
2020
Statut:
ppublish
Résumé
A growing body of empirical evidence supports the notion of diverse neurobiological processes underlying learning-induced plasticity changes in the human brain. There are still open questions about how brain plasticity depends on cognitive task complexity, how it supports interactions between brain systems and with what temporal and spatial trajectory. We investigated brain and behavioural changes in sighted adults during 8-months training of tactile Braille reading whilst monitoring brain structure and function at 5 different time points. We adopted a novel multivariate approach that includes behavioural data and specific MRI protocols sensitive to tissue properties to assess local functional and structural and myelin changes over time. Our results show that while the reading network, located in the ventral occipitotemporal cortex, rapidly adapts to tactile input, sensory areas show changes in grey matter volume and intra-cortical myelin at different times. This approach has allowed us to examine and describe neuroplastic mechanisms underlying complex cognitive systems and their (sensory) inputs and (motor) outputs differentially, at a mesoscopic level.
Identifiants
pubmed: 33307223
pii: S1053-8119(20)31098-3
doi: 10.1016/j.neuroimage.2020.117613
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
117613Informations de copyright
Copyright © 2020. Published by Elsevier Inc.