Fracture toughness of bone at the microscale.

Bone and Bones Collagen Fractures, Bone Humans
Anisotropy Bone Double cantilever beam Fibrils Fracture energy Fracture toughness Micro scale

Journal

Acta biomaterialia
ISSN: 1878-7568
Titre abrégé: Acta Biomater
Pays: England
ID NLM: 101233144

Informations de publication

Date de publication:
02 2021
Historique:
received: 01 10 2020
revised: 12 11 2020
accepted: 03 12 2020
pubmed: 12 12 2020
medline: 15 5 2021
entrez: 11 12 2020
Statut: ppublish

Résumé

Bone's hierarchical arrangement of collagen and mineral generates a confluence of toughening mechanisms acting at every length scale from the molecular to the macroscopic level. Molecular defects, disease, and age alter bone structure at different levels and diminish its fracture resistance. However, the inability to isolate and quantify the influence of specific features hampers our understanding and the development of new therapies. Here, we combine in situ micromechanical testing, transmission electron microscopy and phase-field modelling to quantify intrinsic deformation and toughening at the fibrillar level and unveil the critical role of fibril orientation on crack deflection. At this level dry bone is highly anisotropic, with fracture energies ranging between 5 and 30 J/m

Identifiants

DOI: 10.1016/j.actbio.2020.12.007 PMID: 33307248
pubmed: 33307248
pii: S1742-7061(20)30721-2
doi: 10.1016/j.actbio.2020.12.007
pii:
doi:

Substances chimiques

Collagen 9007-34-5

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

475-483

Subventions

Organisme : Wellcome Trust
ID : WT097347AIA
Pays : United Kingdom

Informations de copyright

Copyright © 2020 Acta Materialia Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest All authors declare they have no competing financial interests.

Auteurs

Nouf Aldegaither (N)

Department of Materials Science & Engineering, Imperial College London, Kensington, London, SW7 2AZ, UK; College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Giorgio Sernicola (G)

Department of Materials Science & Engineering, Imperial College London, Kensington, London, SW7 2AZ, UK.

Ataollah Mesgarnejad (A)

Center for Interdisciplinary Research on Complex Systems, Department of Physics, Northeastern University, Boston, MA, USA.

Alain Karma (A)

Center for Interdisciplinary Research on Complex Systems, Department of Physics, Northeastern University, Boston, MA, USA.

Daniel Balint (D)

Department of Mechanical Engineering, Imperial College London, Kensington, London SW7 2AZ, UK.

Jianglong Wang (J)

Department of Mechanical Engineering, Imperial College London, Kensington, London SW7 2AZ, UK.

Eduardo Saiz (E)

Department of Materials Science & Engineering, Imperial College London, Kensington, London, SW7 2AZ, UK.

Sandra J Shefelbine (SJ)

Department of Mechanical and Industrial Engineering and Department of Bioengineering, Northeastern University, Boston, MA, USA.

Alexandra E Porter (AE)

Department of Materials Science & Engineering, Imperial College London, Kensington, London, SW7 2AZ, UK. Electronic address: a.porter@imperial.ac.uk.

Finn Giuliani (F)

Department of Materials Science & Engineering, Imperial College London, Kensington, London, SW7 2AZ, UK. Electronic address: f.giuliani@imperial.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Tissus › Tissu conjonctif › Os et tissu osseux › Fracture toughness of bone at the microscale.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › Collagène › Fracture toughness of bone at the microscale.
questionsmedicales.fr › Plaies et blessures › Fractures osseuses › Fracture toughness of bone at the microscale.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Fracture toughness of bone at the microscale.