Local treatment for relapsing glioblastoma: A decision-making tree for choosing between reirradiation and second surgery.
Decision-making tree
Recurrent glioblastoma
Reirradiation
Repeat radiotherapy
Repeat surgery
Salvage treatment
Second surgery
Journal
Critical reviews in oncology/hematology
ISSN: 1879-0461
Titre abrégé: Crit Rev Oncol Hematol
Pays: Netherlands
ID NLM: 8916049
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
27
01
2020
revised:
21
05
2020
accepted:
23
11
2020
pubmed:
12
12
2020
medline:
23
1
2021
entrez:
11
12
2020
Statut:
ppublish
Résumé
In case of circumscribed recurrent glioblastoma (rec-GBM), a second surgery (Re-S) and reirradiation (Re-RT) are local strategies to consider. The aim is to provide an algorithm to use in the daily clinical practice. The first step is to consider the life expectancy in order to establish whether the patient should be a candidate for active treatment. In case of a relatively good life expectancy (>3 months) and a confirmed circumscribed disease(i.e. without multiple lesions that are in different lobes/hemispheres), the next step is the assessment of the prognostic factors for local treatments. Based on the existing prognostic score systems, patients who should be excluded from local treatments may be identified; based on the validated prognostic factors, one or the other local treatment may be preferred. The last point is the estimation of expected toxicity, considering patient-related, tumor-related and treatment-related factors impacting on side effects. Lastly, patients with very good prognostic factors may be considered for receiving a combined treatment.
Identifiants
pubmed: 33307416
pii: S1040-8428(20)30320-6
doi: 10.1016/j.critrevonc.2020.103184
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
103184Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.