Changes in oxidation-antioxidation function on the thymus of chickens infected with reticuloendotheliosis virus.
Histopathological and ultrastructural changes
Immunosuppression
Oxidation antioxidant imbalance
Reticuloendotheliosis virus
Thymus
Journal
BMC veterinary research
ISSN: 1746-6148
Titre abrégé: BMC Vet Res
Pays: England
ID NLM: 101249759
Informations de publication
Date de publication:
11 Dec 2020
11 Dec 2020
Historique:
received:
22
05
2020
accepted:
02
12
2020
entrez:
14
12
2020
pubmed:
15
12
2020
medline:
7
7
2021
Statut:
epublish
Résumé
Reticuloendotheliosis virus (REV) is a retrovirus that causes severe immunosuppression in poultry. Animals grow slowly under conditions of oxidative stress. In addition, long-term oxidative stress can impair immune function, as well as accelerate aging and death. This study aimed to elucidate the pathogenesis of REV from the perspective of changes in oxidative-antioxidative function following REV infection. A total of 80 one-day-old specific pathogen free (SPF) chickens were randomly divided into a control group (Group C) and an REV-infected group (Group I). The chickens in Group I received intraperitoneal injections of REV with 10 In chickens infected with REV, the levels of H These results indicate that an increase in oxidative stress enhanced lipid peroxidation, markedly decreased antioxidant function, caused thymus atrophy, and immunosuppression in REV-infected chickens.
Sections du résumé
BACKGROUND
BACKGROUND
Reticuloendotheliosis virus (REV) is a retrovirus that causes severe immunosuppression in poultry. Animals grow slowly under conditions of oxidative stress. In addition, long-term oxidative stress can impair immune function, as well as accelerate aging and death. This study aimed to elucidate the pathogenesis of REV from the perspective of changes in oxidative-antioxidative function following REV infection.
METHODS
METHODS
A total of 80 one-day-old specific pathogen free (SPF) chickens were randomly divided into a control group (Group C) and an REV-infected group (Group I). The chickens in Group I received intraperitoneal injections of REV with 10
RESULTS
RESULTS
In chickens infected with REV, the levels of H
CONCLUSIONS
CONCLUSIONS
These results indicate that an increase in oxidative stress enhanced lipid peroxidation, markedly decreased antioxidant function, caused thymus atrophy, and immunosuppression in REV-infected chickens.
Identifiants
pubmed: 33308224
doi: 10.1186/s12917-020-02708-6
pii: 10.1186/s12917-020-02708-6
pmc: PMC7731740
doi:
Substances chimiques
Antioxidants
0
Hydrogen Peroxide
BBX060AN9V
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
483Subventions
Organisme : National Natural Science Foundation of China
ID : 31472169
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