Association between lifestyle and site-specific advanced colorectal lesions in screening with faecal immunochemical test and sigmoidoscopy.

Aged Alcohol Drinking / epidemiology Biomarkers, Tumor / analysis Colorectal Neoplasms / diagnosis Female Humans Life Style Male Middle Aged Obesity / epidemiology Occult Blood Referral and Consultation / statistics & numerical data Sigmoidoscopy / statistics & numerical data Smoking / epidemiology Surveys and Questionnaires
Alcohol Body mass index CRC screening Proximal neoplasia Smoking

Journal

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
ISSN: 1878-3562
Titre abrégé: Dig Liver Dis
Pays: Netherlands
ID NLM: 100958385

Informations de publication

Date de publication:
03 2021
Historique:
received: 25 08 2020
revised: 14 10 2020
accepted: 19 11 2020
pubmed: 15 12 2020
medline: 24 12 2021
entrez: 14 12 2020
Statut: ppublish

Résumé

Lifestyle factors may help to identify individuals at high-risk for colorectal cancer (CRC). To examine the association between lifestyle, referral for follow-up colonoscopy and proximal neoplasia detection in CRC screening. In this observational study, 14,832 individuals aged 50-74 years were invited to faecal immunochemical test (FIT) or sigmoidoscopy screening. Advanced lesions (AL), including advanced adenomas, advanced serrated lesions and CRC were divided according to location: distal-only, or proximal with or without distal AL. We collected information on smoking habit, body mass index and alcohol intake through a questionnaire. Out of 3,318 FIT and 2,988 sigmoidoscopy participants, 516 (16%) and 338 (11%), respectively, were referred for follow-up colonoscopy after a positive screening test. Two-hundred-and-fifty-six (4%) had distal-only and 119 (2%) proximal AL. In FIT participants, obesity and high alcohol intake were associated with proximal AL; odds ratio (95% confidence interval) 2.68 (1.36-5.26) and 2.16 (1.08-4.30), respectively. In sigmoidoscopy participants, current smoking was associated with proximal AL; 4.58 (2.24-9.38), and current smoking and obesity were associated with referral for colonoscopy; 2.80 (2.02-3.89) and 1.42 (1.01-2.00), respectively. Current smoking, obesity and high alcohol intake were associated with screen-detected proximal colorectal AL. Current smoking and obesity were associated with referral for follow-up colonoscopy in sigmoidoscopy screening.

Sections du résumé

BACKGROUND
Lifestyle factors may help to identify individuals at high-risk for colorectal cancer (CRC).
AIMS
To examine the association between lifestyle, referral for follow-up colonoscopy and proximal neoplasia detection in CRC screening.
METHODS
In this observational study, 14,832 individuals aged 50-74 years were invited to faecal immunochemical test (FIT) or sigmoidoscopy screening. Advanced lesions (AL), including advanced adenomas, advanced serrated lesions and CRC were divided according to location: distal-only, or proximal with or without distal AL. We collected information on smoking habit, body mass index and alcohol intake through a questionnaire.
RESULTS
Out of 3,318 FIT and 2,988 sigmoidoscopy participants, 516 (16%) and 338 (11%), respectively, were referred for follow-up colonoscopy after a positive screening test. Two-hundred-and-fifty-six (4%) had distal-only and 119 (2%) proximal AL. In FIT participants, obesity and high alcohol intake were associated with proximal AL; odds ratio (95% confidence interval) 2.68 (1.36-5.26) and 2.16 (1.08-4.30), respectively. In sigmoidoscopy participants, current smoking was associated with proximal AL; 4.58 (2.24-9.38), and current smoking and obesity were associated with referral for colonoscopy; 2.80 (2.02-3.89) and 1.42 (1.01-2.00), respectively.
CONCLUSION
Current smoking, obesity and high alcohol intake were associated with screen-detected proximal colorectal AL. Current smoking and obesity were associated with referral for follow-up colonoscopy in sigmoidoscopy screening.

Identifiants

DOI: 10.1016/j.dld.2020.11.021 PMID: 33309513
pubmed: 33309513
pii: S1590-8658(20)31042-2
doi: 10.1016/j.dld.2020.11.021
pii:
doi:

Substances chimiques

Biomarkers, Tumor 0

Types de publication

Journal Article Observational Study Randomized Controlled Trial

Langues

eng

Sous-ensembles de citation

IM

Pagination

353-359

Informations de copyright

Copyright © 2020 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

Auteurs

Markus D Knudsen (MD)

Section for colorectal cancer screening, Cancer Registry of Norway, P.O. Box 5313, Majorstuen, 0304 Oslo, Norway; Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Norwegian PSC Research Center, Oslo University Hospital, Rikshospitalet, P.O. Box 4950 Nydalen, 0424 Oslo, Norway; Departments of Epidemiology and Nutrition, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA.

Edoardo Botteri (E)

Section for colorectal cancer screening, Cancer Registry of Norway, P.O. Box 5313, Majorstuen, 0304 Oslo, Norway.

Øyvind Holme (Ø)

Section for colorectal cancer screening, Cancer Registry of Norway, P.O. Box 5313, Majorstuen, 0304 Oslo, Norway; Department of Medicine, Sørlandet Hospital Kristiansand, P.O. Box 416 Lundsiden, 4604 Kristiansand, Norway; Department of Health Management and Health Economis, Institute of Health and Society, University of Oslo, P.O. Box 1089 Blindern, 0317 Oslo, Norway.

Anette Hjartåker (A)

Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O.Box 1046 Blindern, 0317 Oslo, Norway.

Mingyang Song (M)

Departments of Epidemiology and Nutrition, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.

Espen Thiis-Evensen (E)

Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Norwegian PSC Research Center, Oslo University Hospital, Rikshospitalet, P.O. Box 4950 Nydalen, 0424 Oslo, Norway.

Espen R Norvard (ER)

Department of Pathology, Vestre Viken Hospital Trust Drammen, P.O. Box 800, 3004 Drammen, Norway.

Anna L Schult (AL)

Section for colorectal cancer screening, Cancer Registry of Norway, P.O. Box 5313, Majorstuen, 0304 Oslo, Norway; Department of Medicine, Vestre Viken Hospital Trust Bærum, P.O. Box 800, 3004 Drammen, Norway; Institute of Clinical Medicine, University of Oslo, Rikshospitalet, P.O. Box 4950 Nydalen, 0424 Oslo, Norway.

Kristin R Randel (KR)

Section for colorectal cancer screening, Cancer Registry of Norway, P.O. Box 5313, Majorstuen, 0304 Oslo, Norway; Department of Health Management and Health Economis, Institute of Health and Society, University of Oslo, P.O. Box 1089 Blindern, 0317 Oslo, Norway; Department of Research and Development, Telemark Hospital Trust, Ulefossvegen 55, 3710 Skien, Norway.

Geir Hoff (G)

Section for colorectal cancer screening, Cancer Registry of Norway, P.O. Box 5313, Majorstuen, 0304 Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Rikshospitalet, P.O. Box 4950 Nydalen, 0424 Oslo, Norway; Department of Research and Development, Telemark Hospital Trust, Ulefossvegen 55, 3710 Skien, Norway.

Paula Berstad (P)

Section for colorectal cancer screening, Cancer Registry of Norway, P.O. Box 5313, Majorstuen, 0304 Oslo, Norway. Electronic address: paula.berstad@kreftregisteret.no.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Association between lifestyle and...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement dipsique › Consommation d'alcool › Association between lifestyle and...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Association between lifestyle and...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › Association between lifestyle and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Association between lifestyle and...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Mode de vie › Association between lifestyle and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Association between lifestyle and...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Association between lifestyle and...
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Sang occulte › Association between lifestyle and...
questionsmedicales.fr › Administration des services de santé › Organisation et administration › Pratique professionnelle › Orientation vers un spécialiste › Association between lifestyle and...
questionsmedicales.fr › Procédures de chirurgie opératoire › Interventions chirurgicales mini-invasives › Endoscopie › Endoscopie digestive › Endoscopie gastrointestinale › Coloscopie › Rectosigmoïdoscopie › Association between lifestyle and...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Fumer › Association between lifestyle and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Association between lifestyle and...