Fabrication and characterization of conductive polypyrrole/chitosan/collagen electrospun nanofiber scaffold for tissue engineering application.
Biocompatible Materials
/ chemistry
Chitosan
/ chemistry
Collagen
/ chemistry
Electric Conductivity
Humans
Nanofibers
/ chemistry
Polyesters
/ chemistry
Polyethylene Glycols
/ chemistry
Polymers
/ chemistry
Pyrroles
/ chemical synthesis
Spectroscopy, Fourier Transform Infrared
/ methods
Tissue Engineering
/ methods
Tissue Scaffolds
/ chemistry
Electrical conductive polymer
Electrospinning
Nanofiber
Polypyrrole (PPy)
Scaffold
Tissue engineering
Journal
International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578
Informations de publication
Date de publication:
31 Jan 2021
31 Jan 2021
Historique:
received:
28
09
2020
revised:
27
11
2020
accepted:
04
12
2020
pubmed:
15
12
2020
medline:
28
4
2021
entrez:
14
12
2020
Statut:
ppublish
Résumé
Conductive electrospun nanofiber scaffold containing conductive polypyrrole (PPy) polymer was fabricated to accelerate healing of damaged tissues. In order to prepare these scaffolds, various weight percentages of polypyrrole (5, 10, 15, 20, 25%) relative to the polymers combination (chitosan, collagen, and polyethylene oxide) were used. The fabricated composite scaffolds were characterized using chemical, morphological, physio-mechanical, and biological analyses including; FTIR spectroscopy, SEM, electrical conductivity, tensile test, in vitro degradation, MTT Assay and cell culture. The polypyrrole particles were perfectly dispersed inside the nanofibers, and the fibers average diameter were reducing by increasing the polypyrrole content in the composites. The presence of polypyrrole in fibers enhanced their conductivity up to 164.274 × 10
Identifiants
pubmed: 33309657
pii: S0141-8130(20)35189-8
doi: 10.1016/j.ijbiomac.2020.12.031
pii:
doi:
Substances chimiques
Biocompatible Materials
0
Polyesters
0
Polymers
0
Pyrroles
0
polypyrrole
30604-81-0
Polyethylene Glycols
3WJQ0SDW1A
Collagen
9007-34-5
Chitosan
9012-76-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
175-186Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome.