Time to put the mammillothalamic pathway into context.
Amnesia
Anterior thalamic nuclei
Diencephalon
Hippocampus
Mammillary bodies
Memory
Retrosplenial cortex
Journal
Neuroscience and biobehavioral reviews
ISSN: 1873-7528
Titre abrégé: Neurosci Biobehav Rev
Pays: United States
ID NLM: 7806090
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
09
06
2020
revised:
10
10
2020
accepted:
13
11
2020
pubmed:
15
12
2020
medline:
22
6
2021
entrez:
14
12
2020
Statut:
ppublish
Résumé
The medial diencephalon, in particular the mammillary bodies and anterior thalamic nuclei, has long been linked to memory and amnesia. The mammillary bodies provide a dense input into the anterior thalamic nuclei, via the mammillothalamic tract. In both animal models, and in patients, lesions of the mammillary bodies, mammillothalamic tract and anterior thalamic nuclei all produce severe impairments in temporal and contextual memory, yet it is uncertain why these regions are critical. Mounting evidence from electrophysiological and neural imaging studies suggests that mammillothalamic projections exercise considerable distal influence over thalamo-cortical and hippocampo-cortical interactions. Here, we outline how damage to the mammillary body-anterior thalamic axis, in both patients and animal models, disrupts behavioural performance on tasks that relate to contextual ("where") and temporal ("when") processing. Focusing on the medial mammillary nuclei as a possible 'theta-generator' (through their interconnections with the ventral tegmental nucleus of Gudden) we discuss how the mammillary body-anterior thalamic pathway may contribute to the mechanisms via which the hippocampus and neocortex encode representations of experience.
Identifiants
pubmed: 33309908
pii: S0149-7634(20)30675-8
doi: 10.1016/j.neubiorev.2020.11.031
pmc: PMC8137464
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
60-74Subventions
Organisme : Wellcome Trust
ID : WT 212273/Z/18/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.
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