Hexane extract from SpoSndias mombin L. (Anacardiaceae) prevents behavioral and oxidative status changes on model of Parkinson's disease in zebrafish.
Antioxidant activity
Parkinson
Rotenone
Spondias mombin
Zebrafish
Journal
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
ISSN: 1532-0456
Titre abrégé: Comp Biochem Physiol C Toxicol Pharmacol
Pays: United States
ID NLM: 100959500
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
22
07
2020
revised:
04
12
2020
accepted:
06
12
2020
pubmed:
15
12
2020
medline:
6
7
2021
entrez:
14
12
2020
Statut:
ppublish
Résumé
The search for new therapies, derived from natural compounds in order to prevent and treat Parkinson's disease (PD) has aroused the interest of many researchers. Spondias mombin (L) has active constituents with known antioxidant and anti-inflammatory activities. The aim of this study was to evaluate the neuroprotective potential of the hexane extract of S. mombin (EHSm) in an experimental model of DP induced by rotenone in zebrafish. The analysis of GC/MS demonstrated cyclogallipharaol (13.88%) and dl-α-tocopherol (8.08%) mostly, while HPLC-DAD indicated the presence of quercetin (<5), quercetrin (6.54 mg/g) and rutin (8.83 mg/g). The zebrafish exposed for 4 weeks to rotenone (ROT, 3 μg/L) and EHSm (5, 15, 25 mg/L). EHSm (25 mg/L) was able to reverse the behavioral damage induced by ROT in the entries and time spent in the top area of the tank. The parameters biochemicals indicated of EHSm prevented oxidative stress (TBARS e total thiols), inflammation and dopamine uptake triggered by ROT, evidenced of increased on the CAT, SOD and GSH and decreased of GST, O
Identifiants
pubmed: 33310063
pii: S1532-0456(20)30253-2
doi: 10.1016/j.cbpc.2020.108953
pii:
doi:
Substances chimiques
Plant Extracts
0
Rotenone
03L9OT429T
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
108953Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.