Exploring the impact of HIV infection and antiretroviral therapy on placenta morphology.

Adult Anti-Retroviral Agents / pharmacology Female HIV Infections / drug therapy Humans Infant, Newborn Placenta / drug effects Pregnancy Umbilical Cord / drug effects
Marginal cord Marginality Placenta shape Protease inhibitors Small for gestational age Velamentous cord

Journal

Placenta
ISSN: 1532-3102
Titre abrégé: Placenta
Pays: Netherlands
ID NLM: 8006349

Informations de publication

Date de publication:
15 01 2021
Historique:
received: 30 09 2020
revised: 05 11 2020
accepted: 03 12 2020
pubmed: 15 12 2020
medline: 21 12 2021
entrez: 14 12 2020
Statut: ppublish

Résumé

Women living with HIV experience more adverse birth outcomes; the mechanisms are not fully understood. We examined placenta morphology and associations with birth outcomes in a Canadian cohort of women living with HIV (HIV Term placentas from 94 women (40 HIV We observed a trend towards lower placenta weight and smaller placenta area in the HIV Our data suggest that HIV/ART exposure affects placenta morphology and is associated with higher rates of abnormal cord insertion.

Identifiants

DOI: 10.1016/j.placenta.2020.12.004 PMID: 33310298
pubmed: 33310298
pii: S0143-4004(20)30457-4
doi: 10.1016/j.placenta.2020.12.004
pii:
doi:

Substances chimiques

Anti-Retroviral Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102-109

Subventions

Organisme : CIHR
ID : PJT-148684
Pays : Canada
Organisme : CIHR
ID : MOP-130398
Pays : Canada

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Auteurs

Michael Yampolsky (M)

Department of Mathematics, University of Toronto, Toronto, Canada.

Oleksandr Shlakhter (O)

Alberta Health Services, Edmonton, Canada.

Dianna Deng (D)

Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.

Smriti Kala (S)

Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.

Sharon L Walmsley (SL)

Toronto General Hospital Research Institute, University Health Network, Toronto, Canada; Department of Medicine, University of Toronto, Toronto, Canada.

Kellie E Murphy (KE)

Department of Obstetrics and Gynaecology, Sinai Health System, University of Toronto, Toronto, Canada.

Mark H Yudin (MH)

Department of Obstetrics and Gynaecology, St. Michael's Hospital, University of Toronto, Toronto, Canada.

Jay MacGillivray (J)

Department of Obstetrics and Gynaecology, St. Michael's Hospital, University of Toronto, Toronto, Canada; Ryerson University, Toronto, Canada.

Mona Loutfy (M)

Department of Medicine, University of Toronto, Toronto, Canada; Women's College Research Institute, Women's College Hospital, Toronto, Canada.

Caroline Dunk (C)

Research Centre for Women's and Infants' Health, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health System, Toronto, Canada.

Lena Serghides (L)

Toronto General Hospital Research Institute, University Health Network, Toronto, Canada; Women's College Research Institute, Women's College Hospital, Toronto, Canada; Department of Immunology and Institute of Medical Sciences, University of Toronto, Toronto, Canada. Electronic address: lena.serghides@utoronto.ca.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Exploring the impact of HIV infection and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Antirétroviraux › Exploring the impact of HIV infection and...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Exploring the impact of HIV infection and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Exploring the impact of HIV infection and...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Exploring the impact of HIV infection and...
questionsmedicales.fr › Structures de l'embryon › Placenta › Exploring the impact of HIV infection and...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Exploring the impact of HIV infection and...
questionsmedicales.fr › Structures de l'embryon › Foetus › Cordon ombilical › Exploring the impact of HIV infection and...