Centromedian thalamic nucleus with or without anterior thalamic nucleus deep brain stimulation for epilepsy in children and adults: A retrospective case series.
Anterior nucleus
Centromedian
Deep brain stimulation
Epilepsy
Seizure
Thalamus
Journal
Seizure
ISSN: 1532-2688
Titre abrégé: Seizure
Pays: England
ID NLM: 9306979
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
07
06
2020
revised:
17
11
2020
accepted:
20
11
2020
pubmed:
15
12
2020
medline:
29
7
2021
entrez:
14
12
2020
Statut:
ppublish
Résumé
The centromedian (CM) and anterior nucleus of the thalamus (ANT) are deep brain stimulation (DBS) targets for management of generalized, and focal drug resistant epilepsy (DRE), respectively. We report on a single center retrospective case series of 16 children and adults with DRE who underwent CM with simultaneous ANT (69 %) or CM without simultaneous ANT DBS (31 %). Seizure frequency, epilepsy severity, life satisfaction, and quality of sleep before and after DBS were compared. Baseline median seizure frequency was 323 seizures per month (IQR, 71-563 sz/mo). Median follow up time was 80 months (IQR 37-97 mo). Median seizure frequency reduction was 58 % (IQR 13-87 %, p = 0.002). Ten patients (63 %) reported ≥50 % seizure frequency reduction. Median seizure frequency reduction and responder rate were not significantly different for CM + ANT versus CM only. Seizure severity and life satisfaction were significantly improved. Three patients (19 %) developed device-related side effects, 2 of them (12.5 %) required surgical intervention. In a heterogenous population of children and adults with generalized, multifocal, posterior onset, and poorly localized DRE, CM with or without ANT DBS is feasible, relatively safe and is associated with reduced seizure frequency and severity, as well as improved life satisfaction.
Identifiants
pubmed: 33310676
pii: S1059-1311(20)30364-2
doi: 10.1016/j.seizure.2020.11.012
pmc: PMC7856176
mid: NIHMS1653959
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
101-107Subventions
Organisme : NINDS NIH HHS
ID : K23 NS112339
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS092882
Pays : United States
Organisme : NINDS NIH HHS
ID : UH3 NS095495
Pays : United States
Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Références
Continuum (Minneap Minn). 2019 Apr;25(2):477-491
pubmed: 30921019
Epilepsia. 2006 Jul;47(7):1203-12
pubmed: 16886984
Lancet Neurol. 2019 Apr;18(4):357-375
pubmed: 30773428
J Neurosurg. 2020 May 8;:1-10
pubmed: 32384279
Epilepsia. 2015 Jun;56(6):e78-82
pubmed: 25940212
Eur J Neurol. 2015 Jan;22(1):24-30
pubmed: 25367637
JAMA Neurol. 2016 Nov 1;73(11):1370-1372
pubmed: 27654625
Epilepsia. 2010 Jun;51(6):1069-77
pubmed: 19889013
Epilepsia. 1992 Sep-Oct;33(5):841-51
pubmed: 1396427
Epilepsia. 2018 Dec;59(12):2179-2193
pubmed: 30426482
J Clin Neurosci. 2019 May;63:1-7
pubmed: 30827880
AJNR Am J Neuroradiol. 2012 Jun;33(6):1072-80
pubmed: 22300931
Stereotact Funct Neurosurg. 2016;94(3):187-97
pubmed: 27434073
Epilepsy Res. 2019 Jul;153:1-6
pubmed: 30913474
Epilepsia. 2018 Feb;59(2):273-290
pubmed: 29218702
Epilepsia. 2013 Oct;54(10):1823-33
pubmed: 24032641
Epilepsia. 2011 Jun;52(6):1150-9
pubmed: 21671925
Neurosurg Rev. 2019 Jun;42(2):287-296
pubmed: 29306976
Epilepsia. 2011 Dec;52(12):2168-80
pubmed: 21883177
Epilepsia. 2017 Apr;58(4):512-521
pubmed: 28276062
Neuroimage. 2015 Feb 15;107:127-135
pubmed: 25498389
Neurology. 2015 Mar 10;84(10):1017-25
pubmed: 25663221
Epilepsy Behav. 2020 Nov;112:107354
pubmed: 32919199
Epilepsia. 2010 May;51(5):899-908
pubmed: 20331461