Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system.
Animals
Behavior, Animal
Depression
/ complications
Disease Models, Animal
Endocannabinoids
/ pharmacology
Fatty Acids
/ metabolism
Fecal Microbiota Transplantation
Gastrointestinal Microbiome
/ physiology
Lactobacillus
/ physiology
Male
Mice
Mice, Inbred C57BL
Neurogenesis
/ drug effects
Stress, Psychological
/ complications
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
11 12 2020
11 12 2020
Historique:
received:
28
05
2019
accepted:
06
11
2020
entrez:
14
12
2020
pubmed:
15
12
2020
medline:
5
1
2021
Statut:
epublish
Résumé
Depression is the leading cause of disability worldwide. Recent observations have revealed an association between mood disorders and alterations of the intestinal microbiota. Here, using unpredictable chronic mild stress (UCMS) as a mouse model of depression, we show that UCMS mice display phenotypic alterations, which could be transferred from UCMS donors to naïve recipient mice by fecal microbiota transplantation. The cellular and behavioral alterations observed in recipient mice were accompanied by a decrease in the endocannabinoid (eCB) signaling due to lower peripheral levels of fatty acid precursors of eCB ligands. The adverse effects of UCMS-transferred microbiota were alleviated by selectively enhancing the central eCB or by complementation with a strain of the Lactobacilli genus. Our findings provide a mechanistic scenario for how chronic stress, diet and gut microbiota generate a pathological feed-forward loop that contributes to despair behavior via the central eCB system.
Identifiants
pubmed: 33311466
doi: 10.1038/s41467-020-19931-2
pii: 10.1038/s41467-020-19931-2
pmc: PMC7732982
doi:
Substances chimiques
Endocannabinoids
0
Fatty Acids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6363Références
Prog Neuropsychopharmacol Biol Psychiatry. 2016 Jun 3;67:92-7
pubmed: 26780604
Neuropsychopharmacology. 2005 Mar;30(3):508-15
pubmed: 15525997
Neurosci Biobehav Rev. 2012 Jan;36(1):310-40
pubmed: 21777613
Science. 2016 Feb 19;351(6275):854-7
pubmed: 26912894
Pharmacol Res. 2010 May;61(5):400-4
pubmed: 20080186
J Biol Chem. 2002 Nov 29;277(48):46645-50
pubmed: 12237305
Addict Behav. 2006 Apr;31(4):738-42
pubmed: 15964704
Neurogastroenterol Motil. 2013 Sep;25(9):713-9
pubmed: 23910373
Nucleic Acids Res. 2009 Jan;37(Database issue):D141-5
pubmed: 19004872
Nat Methods. 2012 Jun 28;9(7):690-6
pubmed: 22743774
Nat Chem Biol. 2009 Jan;5(1):37-44
pubmed: 19029917
Front Psychiatry. 2015 Feb 02;6:6
pubmed: 25698978
Trends Neurosci. 2013 May;36(5):305-12
pubmed: 23384445
Neurogastroenterol Motil. 2014 Aug;26(8):1155-62
pubmed: 24888394
Curr Opin Biotechnol. 2015 Apr;32:14-20
pubmed: 25308830
Sci Adv. 2017 Aug 16;3(8):e1700585
pubmed: 28835919
Physiol Rep. 2015 May 11;3(5):
pubmed: 25969465
J Pharmacol Exp Ther. 2013 Jun;345(3):492-501
pubmed: 23412396
Neuropsychopharmacology. 2014 Jun;39(7):1763-76
pubmed: 24476943
J Lipid Res. 2008 Feb;49(2):340-8
pubmed: 17991757
FASEB J. 2005 Oct;19(12):1704-6
pubmed: 16037095
BMC Microbiol. 2014 Jul 15;14:189
pubmed: 25028050
Nat Rev Endocrinol. 2016 Mar;12(3):133-43
pubmed: 26678807
JAMA. 2009 Mar 18;301(11):1165-6
pubmed: 19293417
Brain Behav Immun. 2015 Aug;48:186-94
pubmed: 25882912
J Psychiatr Res. 2016 Nov;82:109-18
pubmed: 27491067
Behav Brain Res. 2004 Dec 6;155(2):291-9
pubmed: 15364489
Proc Natl Acad Sci U S A. 2016 May 17;113(20):5706-11
pubmed: 27140611
J Pharmacol Exp Ther. 2003 Sep;306(3):880-8
pubmed: 12808005
Cell Host Microbe. 2012 Sep 13;12(3):277-88
pubmed: 22980325
Neurobiol Stress. 2015 Jan 1;1:81-88
pubmed: 25530984
Sci Rep. 2017 Mar 07;7:43859
pubmed: 28266612
Methods Mol Biol. 2012;829:125-44
pubmed: 22231810
J Clin Invest. 2005 Nov;115(11):3104-16
pubmed: 16224541
Cell. 2016 Nov 3;167(4):915-932
pubmed: 27814521
Curr Protoc Pharmacol. 2013 Jun;Chapter 5:Unit 5.65
pubmed: 23744712
Br J Pharmacol. 2015 Aug;172(16):3950-63
pubmed: 25951750
Appl Microbiol Biotechnol. 2006 Jun;71(2):238-45
pubmed: 16172889
Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):3908-13
pubmed: 8632988
Neuropharmacology. 2017 Nov;126:179-189
pubmed: 28890366
Biochem Biophys Res Commun. 2018 Apr 15;498(4):824-829
pubmed: 29530528
Nat Rev Endocrinol. 2014 Feb;10(2):74-6
pubmed: 24322652
Nature. 2011 Aug 03;476(7361):458-61
pubmed: 21814201
Trends Pharmacol Sci. 2009 Sep;30(9):484-93
pubmed: 19732971
Cell. 2014 Mar 27;157(1):121-41
pubmed: 24679531
Mol Pharmacol. 2004 Aug;66(2):204-8
pubmed: 15266010
Nat Neurosci. 2007 Sep;10(9):1110-5
pubmed: 17726477
Cell. 2016 Dec 1;167(6):1469-1480.e12
pubmed: 27912057
Braz J Psychiatry. 2009 Jun;31(2):145-53
pubmed: 19578688
Sci Rep. 2015 Mar 30;5:9336
pubmed: 25822072
Nature. 2018 Jul;559(7712):98-102
pubmed: 29950730
Nutrition. 2016 Mar;32(3):315-20
pubmed: 26706022
Curr Opin Pharmacol. 2009 Feb;9(1):46-52
pubmed: 19157983
J Lipid Res. 2010 Jun;51(6):1344-53
pubmed: 20129912
Nat Rev Neurosci. 2015 Apr;16(4):189-200
pubmed: 25790864
J Affect Disord. 2016 Sep 15;202:254-7
pubmed: 27288567
Gastroenterology. 2011 Aug;141(2):599-609, 609.e1-3
pubmed: 21683077
BMC Complement Altern Med. 2011 Jul 03;11:53
pubmed: 21722398
J Affect Disord. 2018 Mar 1;228:13-19
pubmed: 29197739
J Biol Chem. 2007 Aug 17;282(33):23892-8
pubmed: 17556369
Pharmacopsychiatry. 2008 Mar;41(2):48-53
pubmed: 18311684
Nat Neurosci. 2015 Oct;18(10):1386-93
pubmed: 26404713
Lancet. 2012 Mar 17;379(9820):1045-55
pubmed: 22189047
Brain Res. 2016 Jan 15;1631:1-12
pubmed: 26620542
Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17808-13
pubmed: 24127592
Curr Opin Neurobiol. 2015 Feb;30:51-8
pubmed: 25240202
Science. 2003 Aug 8;301(5634):805-9
pubmed: 12907793
PLoS One. 2017 Jun 8;12(6):e0178868
pubmed: 28594860
Sci Rep. 2017 Apr 03;7:45942
pubmed: 28368029
Neuropsychopharmacology. 2010 Oct;35(11):2249-61
pubmed: 20664582
Clin Nutr. 2019 Oct;38(5):2053-2064
pubmed: 30266270
Behav Pharmacol. 2003 Dec;14(8):573-82
pubmed: 14665974
Nat Neurosci. 2011 Mar;14(3):345-50
pubmed: 21278728
Front Microbiol. 2019 Jan 14;9:3289
pubmed: 30692975
ScientificWorldJournal. 2013 Dec 29;2013:135142
pubmed: 24470789
Horm Behav. 2003 Jan;43(1):60-6
pubmed: 12614635
Prog Neuropsychopharmacol Biol Psychiatry. 2011 Aug 15;35(7):1774-9
pubmed: 21635931
Cell Rep. 2016 May 31;15(9):1945-56
pubmed: 27210745