Intravenous norepinephrine and mephentermine for maintenance of blood pressure during spinal anaesthesia for caesarean section: An interventional double-blinded randomised trial.
Caesarean delivery
mephentermine
norepinephrine
spinal anaesthesia induced hypotension
Journal
Indian journal of anaesthesia
ISSN: 0019-5049
Titre abrégé: Indian J Anaesth
Pays: India
ID NLM: 0013243
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
08
03
2020
revised:
20
04
2020
accepted:
23
07
2020
entrez:
14
12
2020
pubmed:
15
12
2020
medline:
15
12
2020
Statut:
ppublish
Résumé
Spinal anaesthesia induced hypotension (SAIH) and bradycardia may prove deleterious to both parturient and baby, hence vasopressors play a vital role in their management. Recent studies on norepinephrine as rescue vasopressor during subarachnoid block (SAB) enlighten its role for SAIH. This randomised double-blind trial was conducted to compare the effect of intermittent intravenous boluses of norepinephrine and frequently used mephentermine for management of SAIH in caesarean section (CS) to prove whether norepinephrine produces comparable effects or superior to mephentermine. After approval from Institutional Ethics Committee and registration in Clinical Trials Registry India (CTRI/2019/06/019652), 256 parturients posted for elective CS under SAB were randomly allocated into Group-N and Group-M ( The changes in SBP and DBP were comparable in both the groups. It was significantly low after SAB compared to baseline and significantly high compared to 1 Intravenous norepinephrine is better than mephentermine with respect to high response% and stable maternal HR although both are equally effective in maintaining blood pressure following SAIH during elective CS.
Sections du résumé
BACKGROUND AND AIMS
OBJECTIVE
Spinal anaesthesia induced hypotension (SAIH) and bradycardia may prove deleterious to both parturient and baby, hence vasopressors play a vital role in their management. Recent studies on norepinephrine as rescue vasopressor during subarachnoid block (SAB) enlighten its role for SAIH. This randomised double-blind trial was conducted to compare the effect of intermittent intravenous boluses of norepinephrine and frequently used mephentermine for management of SAIH in caesarean section (CS) to prove whether norepinephrine produces comparable effects or superior to mephentermine.
METHODS
METHODS
After approval from Institutional Ethics Committee and registration in Clinical Trials Registry India (CTRI/2019/06/019652), 256 parturients posted for elective CS under SAB were randomly allocated into Group-N and Group-M (
RESULTS
RESULTS
The changes in SBP and DBP were comparable in both the groups. It was significantly low after SAB compared to baseline and significantly high compared to 1
CONCLUSION
CONCLUSIONS
Intravenous norepinephrine is better than mephentermine with respect to high response% and stable maternal HR although both are equally effective in maintaining blood pressure following SAIH during elective CS.
Identifiants
pubmed: 33311725
doi: 10.4103/ija.IJA_91_20
pii: IJA-64-235
pmc: PMC7714008
doi:
Types de publication
Journal Article
Langues
eng
Pagination
S235-S241Informations de copyright
Copyright: © 2020 Indian Journal of Anaesthesia.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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