Genome-wide expression changes induced by bisphenol A, F and S in human stem cell derived hepatocyte-like cells.
bisphenol A
bisphenol F
bisphenol S
hepatocyte-like cells
liver
pluripotent stem cell
Journal
EXCLI journal
ISSN: 1611-2156
Titre abrégé: EXCLI J
Pays: Germany
ID NLM: 101299402
Informations de publication
Date de publication:
2020
2020
Historique:
received:
22
09
2020
accepted:
28
10
2020
entrez:
14
12
2020
pubmed:
15
12
2020
medline:
15
12
2020
Statut:
epublish
Résumé
The debate about possible adverse effects of bisphenol A (BPA) has been ongoing for decades. Bisphenol F (BPF) and S (BPS) have been suggested as "safer" alternatives. In the present study we used hepatocyte-like cells (HLCs) derived from the human embryonic stem cell lines Man12 and H9 to compare the three bisphenol derivatives. Stem cell-derived progenitors were produced using an established system and were exposed to BPA, BPF and BPS for 8 days during their transition to HLCs. Subsequently, we examined cell viability, inhibition of cytochrome P450 (CYP) activity, and genome-wide RNA profiles. Sub-cytotoxic, inhibitory concentrations (IC
Identifiants
pubmed: 33312107
doi: 10.17179/excli2020-2934
pii: 2020-2934
pmc: PMC7726493
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1459-1476Subventions
Organisme : Chief Scientist Office
ID : TCS/16/37
Pays : United Kingdom
Informations de copyright
Copyright © 2020 Lucendo-Villarin et al.
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