Is Idiopathic Hypersomnia a Circadian Rhythm Disorder?
Idiopathic hypersomnia
circadian rhythm genetics
circadian rhythm sleep wake disorders
delayed sleep phase syndrome
sleep drunkenness
sleep inertia
Journal
Current sleep medicine reports
ISSN: 2198-6401
Titre abrégé: Curr Sleep Med Rep
Pays: Switzerland
ID NLM: 101649332
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
entrez:
14
12
2020
pubmed:
15
12
2020
medline:
15
12
2020
Statut:
ppublish
Résumé
The pathophysiology of idiopathic hypersomnia remains unclear, but some of its clinical features suggest the possibility of circadian dysfunction. This review will provide an overview of recent studies of circadian biology that have begun to elucidate the potential role of circadian rhythm dysfunction in idiopathic hypersomnia. Clinically, people with idiopathic hypersomnia tend to have both a late chronotype and prominent sleep inertia or sleep drunkenness. Melatonin and cortisol profiles in people with IH confirm this tendency toward phase delay. More recently, it has been suggested that the night phase as defined by melatonin profile or period length as defined by BMA1 in dermal fibroblasts may also be prolonged in people with IH. Additionally, amplitude of melatonin rhythm and circadian gene expression, particularly BMAL1, PER1, and PER2, may be impaired in this disease. Clinical features, melatonin profiles, and circadian gene expression all suggest abnormalities of the circadian system may be a contributor to the pathogenesis of IH.
Identifiants
pubmed: 33312847
doi: 10.1007/s40675-019-00154-x
pmc: PMC7731890
mid: NIHMS1544510
doi:
Types de publication
Journal Article
Langues
eng
Pagination
201-206Subventions
Organisme : NINDS NIH HHS
ID : K23 NS083748
Pays : United States
Déclaration de conflit d'intérêts
Conflicts of Interest: Dr. Trotti reports fees to her institution from Jazz Pharmaceuticals, Balance Therapeutics, and Harmony Biosciences, outside this work. There are no financial or other conflicts of interest related to this article.
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