Development and validation of language and visuospatial composite scores in ADNI.
Alzheimer's Disease Neuroimaging Initiative
cognition
language
longitudinal analysis
magnetic resonance imaging
psychometrics
visuospatial functioning
Journal
Alzheimer's & dementia (New York, N. Y.)
ISSN: 2352-8737
Titre abrégé: Alzheimers Dement (N Y)
Pays: United States
ID NLM: 101650118
Informations de publication
Date de publication:
2020
2020
Historique:
received:
15
07
2020
accepted:
28
07
2020
entrez:
14
12
2020
pubmed:
15
12
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Composite scores may be useful to summarize overall language or visuospatial functioning in studies of older adults. We used item response theory to derive composite measures for language (ADNI-Lan) and visuospatial functioning (ADNI-VS) from the cognitive battery administered in the Alzheimer's Disease Neuroimaging Initiative (ADNI). We evaluated the scores among groups of people with normal cognition, mild cognitive impairment (MCI), and Alzheimer's disease (AD) in terms of responsiveness to change, association with imaging findings, and ability to differentiate between MCI participants who progressed to AD dementia and those who did not progress. ADNI-Lan and ADNI-VS were able to detect change over time and predict conversion from MCI to AD. They were associated with most of the pre-specified magnetic resonance imaging measures. ADNI-Lan had strong associations with a cerebrospinal fluid biomarker pattern. ADNI-Lan and ADNI-VS may be useful composites for language and visuospatial functioning in ADNI.
Identifiants
pubmed: 33313380
doi: 10.1002/trc2.12072
pii: TRC212072
pmc: PMC7718716
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12072Subventions
Organisme : NIGMS NIH HHS
ID : SC3 GM122662
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG029672
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066509
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG066567
Pays : United States
Organisme : NIA NIH HHS
ID : K25 AG055620
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005136
Pays : United States
Informations de copyright
© 2020 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
Références
Qual Life Res. 2006 Sep;15(7):1179-90
pubmed: 17001438
Neuropsychologia. 2016 May;85:301-9
pubmed: 27037044
Brain Imaging Behav. 2012 Dec;6(4):502-16
pubmed: 22782295
Brain. 2018 Mar 1;141(3):848-862
pubmed: 29360947
J Speech Lang Hear Res. 2019 Mar 25;62(3):706-722
pubmed: 30950734
J Int Neuropsychol Soc. 2018 Aug;24(7):693-702
pubmed: 29706146
Alzheimers Dement. 2010 May;6(3):212-20
pubmed: 20451869
J Am Geriatr Soc. 2005 Apr;53(4):695-9
pubmed: 15817019
Curr Alzheimer Res. 2015;12(7):632-9
pubmed: 26027808
Neurology. 1984 Jul;34(7):939-44
pubmed: 6610841
Neurosci Lett. 2011 Jan 10;487(3):421-5
pubmed: 21055445
Alzheimers Dement (N Y). 2020 Dec 05;6(1):e12072
pubmed: 33313380
J Neuropathol Exp Neurol. 2015 Nov;74(11):1086-92
pubmed: 26469250
J Neuropsychiatry Clin Neurosci. 2005 Fall;17(4):533-40
pubmed: 16387994
Mol Psychiatry. 2020 Nov;25(11):2942-2951
pubmed: 30514930
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
J Nucl Med. 2019 Nov;60(11):1611-1621
pubmed: 30926651
J Alzheimers Dis. 2012;31 Suppl 3:S117-35
pubmed: 22810101
Brain Lang. 2017 Sep;172:22-29
pubmed: 28577822
Neurology. 2015 Sep 1;85(9):790-8
pubmed: 26245925
Alzheimer Dis Assoc Disord. 1997;11 Suppl 2:S13-21
pubmed: 9236948
Alzheimers Dement (Amst). 2016 Nov 05;6:171-181
pubmed: 28275699
Ann Neurol. 2009 Apr;65(4):403-13
pubmed: 19296504
Hum Brain Mapp. 2018 Mar;39(3):1391-1402
pubmed: 29265695
Alzheimers Dement. 2010 May;6(3):202-11.e7
pubmed: 20451868
J Int Neuropsychol Soc. 2008 Sep;14(5):746-59
pubmed: 18764970
Brain Imaging Behav. 2012 Dec;6(4):517-27
pubmed: 22644789
J Neurol Sci. 2013 Oct 15;333(1-2):5-8
pubmed: 23978422
Phys Life Rev. 2009 Sep;6(3):121-43
pubmed: 20161054
Neuropsychology. 2008 Sep;22(5):553-62
pubmed: 18763875
Neurology. 1993 Nov;43(11):2412-4
pubmed: 8232972
Alzheimers Dement (N Y). 2019 Feb 26;5:61-69
pubmed: 30859122
Nat Rev Neurosci. 2007 May;8(5):393-402
pubmed: 17431404
Dement Geriatr Cogn Disord. 2017;43(5-6):229-236
pubmed: 28351035
Arch Neurol. 2010 Aug;67(8):949-56
pubmed: 20697045