Kidney inflammaging is promoted by CCR2
Aging
CCR2
CD73
Inflammaging
Kidney
Macrophages
Mesenchymal stromal cells
Senescence
Journal
Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
24
07
2020
accepted:
19
11
2020
revised:
04
11
2020
pubmed:
15
12
2020
medline:
28
4
2021
entrez:
14
12
2020
Statut:
ppublish
Résumé
The incidence of disorders associated with low inflammatory state, such as chronic kidney disease, increases in the elderly. The accumulation of senescent cells during aging and the senescence-associated secretory phenotype, which leads to inflammaging, is known to be deleterious and account for progressive organ dysfunction. To date, the cellular actors implicated in chronic inflammation in the kidney during aging are still not well characterized. Using the DECyt method, based on hierarchical clustering of flow cytometry data, we showed that aging was associated with significant changes in stromal cell diversity in the kidney. In particular, we identified two cell populations up-regulated with aging, the mesenchymal stromal cell subset (kMSC) expressing CD73 and the monocyte-derived Ly6C
Identifiants
pubmed: 33313981
doi: 10.1007/s00018-020-03719-0
pii: 10.1007/s00018-020-03719-0
pmc: PMC8038964
doi:
Substances chimiques
CX3C Chemokine Receptor 1
0
Ccr2 protein, mouse
0
Cx3cr1 protein, mouse
0
Cytokines
0
Receptors, CCR2
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3485-3501Références
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