Pharmacokinetics and bioavailability of furosemide in sheep.
bioavailability
furosemide
pharmacokinetics
sheep
Journal
Journal of veterinary pharmacology and therapeutics
ISSN: 1365-2885
Titre abrégé: J Vet Pharmacol Ther
Pays: England
ID NLM: 7910920
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
revised:
10
11
2020
received:
16
06
2020
accepted:
23
11
2020
pubmed:
15
12
2020
medline:
25
11
2021
entrez:
14
12
2020
Statut:
ppublish
Résumé
The pharmacokinetics and bioavailability of furosemide were determined following intravenous (IV), intramuscular (IM), and subcutaneous (SC) administrations at 2.5 mg/kg dose in sheep. The study was conducted on six healthy sheep in a three-way, three-period, crossover pharmacokinetic design with a 15-day washout period. In first period, furosemide was randomly administered via IV to 2 sheep, IM to 2 sheep and SC to 2 sheep. In second and third periods, each sheep received furosemide via different routes of administration with the 15-day washout period. Plasma concentrations were determined using a high-performance liquid chromatography assay and analyzed by noncompartmental method. The mean total clearance and volume of distribution at steady state following IV administration were 0.24 L h
Substances chimiques
Furosemide
7LXU5N7ZO5
Types de publication
Journal Article
Randomized Controlled Trial, Veterinary
Langues
eng
Sous-ensembles de citation
IM
Pagination
657-662Subventions
Organisme : The Coordination of Scientific Research Projects, University of Kastamonu, Turkey
ID : KU-BAP01/2019-44
Informations de copyright
© 2020 John Wiley & Sons Ltd.
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