Cyclic Peptidyl Inhibitors against CAL/CFTR Interaction for Treatment of Cystic Fibrosis.
Amino Acid Sequence
Binding Sites
Cell Line, Tumor
Cell Survival
/ drug effects
Cystic Fibrosis
/ drug therapy
Cystic Fibrosis Transmembrane Conductance Regulator
/ antagonists & inhibitors
Drug Stability
Humans
Kinetics
Ligands
Molecular Docking Simulation
Mutation
PDZ Domains
Peptides, Cyclic
/ chemistry
Permeability
/ drug effects
Phosphoproteins
/ chemistry
Sodium-Hydrogen Exchangers
/ chemistry
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
24 12 2020
24 12 2020
Historique:
pubmed:
15
12
2020
medline:
3
2
2021
entrez:
14
12
2020
Statut:
ppublish
Résumé
Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (
Identifiants
pubmed: 33314931
doi: 10.1021/acs.jmedchem.0c01528
pmc: PMC8011814
mid: NIHMS1682093
doi:
Substances chimiques
CFTR protein, human
0
Ligands
0
Peptides, Cyclic
0
Phosphoproteins
0
Sodium-Hydrogen Exchangers
0
sodium-hydrogen exchanger regulatory factor
0
Cystic Fibrosis Transmembrane Conductance Regulator
126880-72-6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
15773-15784Subventions
Organisme : NCI NIH HHS
ID : R01 CA234124
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM110406
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM122459
Pays : United States
Organisme : NIH HHS
ID : S10 OD018507
Pays : United States
Références
Science. 1989 Sep 8;245(4922):1066-73
pubmed: 2475911
Hum Mol Genet. 1998 Nov;7(12):1913-9
pubmed: 9811935
J Cyst Fibros. 2020 Sep;19(5):752-761
pubmed: 32565193
Ann Am Thorac Soc. 2016 Jul;13(7):1173-9
pubmed: 27078236
Angew Chem Int Ed Engl. 2010 Dec 17;49(51):9912-6
pubmed: 21105032
Cell Commun Signal. 2010 May 28;8:8
pubmed: 20509869
Science. 1989 Sep 8;245(4922):1059-65
pubmed: 2772657
Front Pharmacol. 2018 Sep 27;9:1100
pubmed: 30319426
Structure. 2014 Jan 7;22(1):82-93
pubmed: 24210758
J Cell Sci. 2001 Sep;114(Pt 18):3219-31
pubmed: 11591811
ACS Chem Biol. 2013 Feb 15;8(2):423-31
pubmed: 23130658
J Cyst Fibros. 2017 Nov;16 Suppl 2:S50-S61
pubmed: 28986027
J Vis Exp. 2014 Dec 05;(94):
pubmed: 25549242
Angew Chem Int Ed Engl. 2010 Dec 17;49(51):9907-11
pubmed: 21105033
N Engl J Med. 2018 Oct 25;379(17):1612-1620
pubmed: 30334692
Annu Rev Med. 2019 Jan 27;70:197-210
pubmed: 30312551
J Biol Chem. 2004 Jan 16;279(3):1892-8
pubmed: 14570915
N Engl J Med. 1998 Sep 3;339(10):653-8
pubmed: 9725922
Gastroenterol Hepatol (N Y). 2016 Jan;12(1):43-7
pubmed: 27330503
J Med Chem. 2006 Oct 19;49(21):6177-96
pubmed: 17034125
Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18825-30
pubmed: 19846789
FEBS Lett. 1998 May 1;427(1):103-8
pubmed: 9613608
Nat Genet. 2013 Oct;45(10):1160-7
pubmed: 23974870
Nat Commun. 2017 Aug 30;8(1):398
pubmed: 28855508
Chem Commun (Camb). 2015 Feb 7;51(11):2162-5
pubmed: 25554998
PLoS One. 2014 Aug 19;9(8):e103650
pubmed: 25136860
Sci Rep. 2019 Jan 24;9(1):500
pubmed: 30679531
Ann Transl Med. 2018 Sep;6(17):334
pubmed: 30306073
N Engl J Med. 2005 May 12;352(19):1992-2001
pubmed: 15888700
ACS Chem Biol. 2020 Sep 18;15(9):2485-2492
pubmed: 32786250
Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18843-8
pubmed: 21976485
Ther Adv Chronic Dis. 2016 May;7(3):170-83
pubmed: 27347364
Biochemistry. 2008 Sep 23;47(38):10084-98
pubmed: 18754678
Biosci Rep. 2018 Jul 6;38(4):
pubmed: 29472314
J Biol Chem. 2007 Mar 16;282(11):8099-109
pubmed: 17158866
J Biol Chem. 1998 Jul 31;273(31):19797-801
pubmed: 9677412
Angew Chem Int Ed Engl. 2015 May 11;54(20):5874-8
pubmed: 25785567
Biochemistry. 2016 May 10;55(18):2601-12
pubmed: 27089101
Science. 1989 Sep 8;245(4922):1073-80
pubmed: 2570460
Cell Mol Life Sci. 2017 Jan;74(1):39-55
pubmed: 27699454