Deciphering Adipose Tissue Extracellular Vesicles Protein Cargo and Its Role in Obesity.
adipose tissue
biomarkers
exosomes
extracellular vesicles
obesity
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
09 Dec 2020
09 Dec 2020
Historique:
received:
02
11
2020
revised:
03
12
2020
accepted:
04
12
2020
entrez:
15
12
2020
pubmed:
16
12
2020
medline:
3
3
2021
Statut:
epublish
Résumé
The extracellular vesicles (EVs) have emerged as key players in metabolic disorders rising as an alternative way of paracrine/endocrine communication. In particular, in relation to adipose tissue (AT) secreted EVs, the current knowledge about its composition and function is still very limited. Nevertheless, those vesicles have been lately suggested as key players in AT communication at local level, and also with other metabolic peripheral and central organs participating in physiological homoeostasis, and also contributing to the metabolic deregulation related to obesity, diabetes, and associated comorbidities. The aim of this review is to summarize the most relevant data around the EVs secreted by adipose tissue, and especially in the context of obesity, focusing in its protein cargo. The description of the most frequent proteins identified in EVs shed by AT and its components, including their changes under pathological status, will give the reader a whole picture about the membrane/antigens, and intracellular proteins known so far, in an attempt to elucidate functional roles, and also suggesting biomarkers and new paths of therapeutic action.
Identifiants
pubmed: 33316953
pii: ijms21249366
doi: 10.3390/ijms21249366
pmc: PMC7764772
pii:
doi:
Substances chimiques
Proteome
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Instituto de Salud Carlos III
ID : PI16/01212/PI19/00305
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