Influence of Dextran Molecular Weight on the Physical Properties of Magnetic Nanoparticles for Hyperthermia and MRI Applications.
MRI
dextran
diameter
magnetic fluid
magnetic hyperthermia
magnetic nanoparticles
physical properties
relaxivity
Journal
Nanomaterials (Basel, Switzerland)
ISSN: 2079-4991
Titre abrégé: Nanomaterials (Basel)
Pays: Switzerland
ID NLM: 101610216
Informations de publication
Date de publication:
09 Dec 2020
09 Dec 2020
Historique:
received:
18
11
2020
revised:
30
11
2020
accepted:
07
12
2020
entrez:
15
12
2020
pubmed:
16
12
2020
medline:
16
12
2020
Statut:
epublish
Résumé
Dextran-coated magnetic nanoparticles are promising biocompatible agents in various biomedical applications, including hyperthermia and magnetic resonance imaging (MRI). However, the influence of dextran molecular weight on the physical properties of dextran-coated magnetic nanoparticles has not been described sufficiently. We synthesise magnetite nanoparticles with a dextran coating using a co-precipitation method and study their physical properties as a function of dextran molecular weight. Several different methods are used to determine the size distribution of the particles, including microscopy, dynamic light scattering, differential centrifugal sedimentation and magnetic measurements. The size of the dextran-coated particles increases with increasing dextran molecular weight. We find that the molecular weight of dextran has a significant effect on the particle size, efficiency, magnetic properties and specific absorption rate. Magnetic hyperthermia measurements show that heating is faster for dextran-coated particles with higher molecular weight. The different molecular weights of the coating also significantly affected its MRI relaxation properties, especially the transversal relaxivity
Identifiants
pubmed: 33317168
pii: nano10122468
doi: 10.3390/nano10122468
pmc: PMC7763203
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministry of Health of the Slovak Republic
ID : 2018/11-UKMT-7
Organisme : Competence Centre Martin
ID : ITMS code: 26220220153
Organisme : COST action MyWave
ID : COST CA17115
Organisme : EUREKA project E!9982-NANORADIOMAG
ID : E!9982
Organisme : National Grant Agency VEGA
ID : VEGA 2/0033/19
Organisme : APVV
ID : APVV SK-SRB-18-0055
Organisme : APVV
ID : APVV-DS-FR-19-0052
Organisme : project MODEX supported by the Operational Programme Integrated Infrastructure (OPII) funded by the ERDF
ID : ITMS 313011T548
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