Early Neurological Change After Ischemic Stroke Is Associated With 90-Day Outcome.

Aged Aged, 80 and over Female Humans Ischemic Stroke Male Middle Aged Recovery of Function Severity of Illness Index
genome-wide association study phenotype population stroke, ischemic

Journal

Stroke
ISSN: 1524-4628
Titre abrégé: Stroke
Pays: United States
ID NLM: 0235266

Informations de publication

Date de publication:
01 2021
Historique:
pubmed: 16 12 2020
medline: 17 4 2021
entrez: 15 12 2020
Statut: ppublish

Résumé

Large-scale observational studies of acute ischemic stroke (AIS) promise to reveal mechanisms underlying cerebral ischemia. However, meaningful quantitative phenotypes attainable in large patient populations are needed. We characterize a dynamic metric of AIS instability, defined by change in National Institutes of Health Stroke Scale score (NIHSS) from baseline to 24 hours baseline to 24 hours (NIHSS Patients with NIHSS prospectively recorded within 6 hours after onset and then 24 hours later were enrolled in the GENISIS study (Genetics of Early Neurological Instability After Ischemic Stroke). Stepwise linear regression determined variables that independently influenced ΔNIHSS For 2555 patients with AIS, median baseline NIHSS was 9 (interquartile range, 4-16), and median ΔNIHSS The dynamic phenotype, ΔNIHSS

Sections du résumé

BACKGROUND AND PURPOSE
Large-scale observational studies of acute ischemic stroke (AIS) promise to reveal mechanisms underlying cerebral ischemia. However, meaningful quantitative phenotypes attainable in large patient populations are needed. We characterize a dynamic metric of AIS instability, defined by change in National Institutes of Health Stroke Scale score (NIHSS) from baseline to 24 hours baseline to 24 hours (NIHSS
METHODS
Patients with NIHSS prospectively recorded within 6 hours after onset and then 24 hours later were enrolled in the GENISIS study (Genetics of Early Neurological Instability After Ischemic Stroke). Stepwise linear regression determined variables that independently influenced ΔNIHSS
RESULTS
For 2555 patients with AIS, median baseline NIHSS was 9 (interquartile range, 4-16), and median ΔNIHSS
CONCLUSIONS
The dynamic phenotype, ΔNIHSS

Identifiants

DOI: 10.1161/STROKEAHA.119.028687 PMID: 33317415 PMC: PMC7769959
pubmed: 33317415
doi: 10.1161/STROKEAHA.119.028687
pmc: PMC7769959
mid: NIHMS1648886
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

132-141

Subventions

Organisme : NIA NIH HHS
ID : P30 AG066444
Pays : United States
Organisme : NINDS NIH HHS
ID : U24 NS107230
Pays : United States
Organisme : NINDS NIH HHS
ID : K23 NS099487
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS085419
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005681
Pays : United States

Commentaires et corrections

Type : CommentIn

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Auteurs

Laura Heitsch (L)

Division of Emergency Medicine (L.H.), Washington University School of Medicine, St Louis, MO.
Department of Neurology (L.H., M.M.B., A.L.F., R.D., J.-M.L.), Washington University School of Medicine, St Louis, MO.

Laura Ibanez (L)

Department of Psychiatry (L.I., C. Cruchaga), Washington University School of Medicine, St Louis, MO.

Caty Carrera (C)

Neurovascular Research Laboratory and Neurovascular Unit, Vall d'Hebron Institute of Research (VHIR) (C. Carrera, A.B., I.F.-C., J.M.), Universitat Autonoma de Barcelona, Spain.
Department of Neurology, Hospital Universitari Vall d"Hebron (C. Carrera, A.B., M.R., C.M.), Universitat Autonoma de Barcelona, Spain.

Michael M Binkley (MM)

Division of Emergency Medicine (L.H.), Washington University School of Medicine, St Louis, MO.

Daniel Strbian (D)

Department of Neurology, Helsinki University Hospital, Finland (D.S., T.T.).

Turgut Tatlisumak (T)

Department of Neurology, Helsinki University Hospital, Finland (D.S., T.T.).
Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg and Department of Neurology, Sahlgrenska University Hospital, Sweden (T.T.).

Alejandro Bustamante (A)

Neurovascular Research Laboratory and Neurovascular Unit, Vall d'Hebron Institute of Research (VHIR) (C. Carrera, A.B., I.F.-C., J.M.), Universitat Autonoma de Barcelona, Spain.
Department of Neurology, Hospital Universitari Vall d"Hebron (C. Carrera, A.B., M.R., C.M.), Universitat Autonoma de Barcelona, Spain.

Marc Ribó (M)

Department of Neurology, Hospital Universitari Vall d"Hebron (C. Carrera, A.B., M.R., C.M.), Universitat Autonoma de Barcelona, Spain.

Carlos Molina (C)

Department of Neurology, Hospital Universitari Vall d"Hebron (C. Carrera, A.B., M.R., C.M.), Universitat Autonoma de Barcelona, Spain.

Antoni Dávalos (A)

Department of Neurology, Hospital Universitari Germans Trias I Pujol, Badalona, Spain (A.D.).

Elena López-Cancio (E)

Department of Neurology, Hospital Universitario Central de Asturias (HUCA), Oviedo, Spain (E.L.-C.).

Lucia Muñoz-Narbona (L)

Institut Hospital del Mar d'Investigacions Mediques (IMIM), Barcelona, Spain (L.M.-N., C.S.-T., E.G.-S., J.R., J.J.-C.).

Carol Soriano-Tárraga (C)

Institut Hospital del Mar d'Investigacions Mediques (IMIM), Barcelona, Spain (L.M.-N., C.S.-T., E.G.-S., J.R., J.J.-C.).

Eva Giralt-Steinhauer (E)

Institut Hospital del Mar d'Investigacions Mediques (IMIM), Barcelona, Spain (L.M.-N., C.S.-T., E.G.-S., J.R., J.J.-C.).
Department of Neurology, Hospital de Mar, Barcelona, Spain (E.G.-S., J.R., J.J.-C.).

Victor Obach (V)

Department of Neuroscience, Hospital Clinic, University of Barcelona and August Pi I Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain (V.O.).

Agnieszka Slowik (A)

Department of Neurology (A.S., J.P., J.D.), Jagiellonian University Medical College, Krakow, Poland.

Joanna Pera (J)

Department of Neurology (A.S., J.P., J.D.), Jagiellonian University Medical College, Krakow, Poland.

Katarzyna Lapicka-Bodzioch (K)

Department of Neurogenetics (K.L.-B.), Jagiellonian University Medical College, Krakow, Poland.

Justyna Derbisz (J)

Department of Neurology (A.S., J.P., J.D.), Jagiellonian University Medical College, Krakow, Poland.

Tomás Sobrino (T)

Clinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela, Hospital Clinico Universitario, Universidade de Santiago de Compostela, Spain (T.S., J.C., F.C., E.R.-C., S.A.-R.).
Department of Neurology, Hospital Universitario de Albacete, Spain (T.S., G.S.-H.).

José Castillo (J)

Clinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela, Hospital Clinico Universitario, Universidade de Santiago de Compostela, Spain (T.S., J.C., F.C., E.R.-C., S.A.-R.).

Francisco Campos (F)

Clinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela, Hospital Clinico Universitario, Universidade de Santiago de Compostela, Spain (T.S., J.C., F.C., E.R.-C., S.A.-R.).

Emilio Rodríguez-Castro (E)

Clinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela, Hospital Clinico Universitario, Universidade de Santiago de Compostela, Spain (T.S., J.C., F.C., E.R.-C., S.A.-R.).

Susana Arias-Rivas (S)

Clinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela, Hospital Clinico Universitario, Universidade de Santiago de Compostela, Spain (T.S., J.C., F.C., E.R.-C., S.A.-R.).

Tomas Segura (T)

Clinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela, Hospital Clinico Universitario, Universidade de Santiago de Compostela, Spain (T.S., J.C., F.C., E.R.-C., S.A.-R.).
Department of Neurology, Hospital Universitario de Albacete, Spain (T.S., G.S.-H.).

Gemma Serrano-Heras (G)

Department of Neurology, Hospital Universitario de Albacete, Spain (T.S., G.S.-H.).

Cristófol Vives-Bauza (C)

Department of Neurology, Son Espases University Hospital, IdISBa, Palma de Mallorca, Spain (C.V.-B., R.D.-N., S.T., C.J.).

Rosa Díaz-Navarro (R)

Department of Neurology, Son Espases University Hospital, IdISBa, Palma de Mallorca, Spain (C.V.-B., R.D.-N., S.T., C.J.).

Silva Tur (S)

Department of Neurology, Son Espases University Hospital, IdISBa, Palma de Mallorca, Spain (C.V.-B., R.D.-N., S.T., C.J.).

Carmen Jimenez (C)

Department of Neurology, Son Espases University Hospital, IdISBa, Palma de Mallorca, Spain (C.V.-B., R.D.-N., S.T., C.J.).

Joan Martí-Fàbregas (J)

Department of Neurology, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain (J.M.-F., R.D.-M.).

Raquel Delgado-Mederos (R)

Department of Neurology, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain (J.M.-F., R.D.-M.).

Juan Arenillas (J)

Department of Neurology, Hospital Clinico Universitario de Valladolid, Spain (J.A.).

Jerzy Krupinski (J)

Department of Neurology, Hospital Mutua de Terrassa, Spain (J.K., I.F.-C.).
School of Life Sciences, Centre for Biosciences, Manchester Met University, United Kingdom (J.K.).

Natalia Cullell (N)

Stroke Pharmacogenomics and Genetics, Fundacio Docencia I Recerca Mutua de Terrassa, Spain (N.C., E.M., J.C.-M., I.F.-C.).
Stroke Pharmacogenomics and Genetics, Sant Pau Institute of Research, Sant Pau Hospital, Barcelona, Spain (N.C., N.P.T.-A., E.M., J.C.-M.).

Nuria P Torres-Aguila (NP)

Stroke Pharmacogenomics and Genetics, Sant Pau Institute of Research, Sant Pau Hospital, Barcelona, Spain (N.C., N.P.T.-A., E.M., J.C.-M.).

Elena Muiño (E)

Stroke Pharmacogenomics and Genetics, Fundacio Docencia I Recerca Mutua de Terrassa, Spain (N.C., E.M., J.C.-M., I.F.-C.).
Stroke Pharmacogenomics and Genetics, Sant Pau Institute of Research, Sant Pau Hospital, Barcelona, Spain (N.C., N.P.T.-A., E.M., J.C.-M.).

Jara Cárcel-Márquez (J)

Stroke Pharmacogenomics and Genetics, Fundacio Docencia I Recerca Mutua de Terrassa, Spain (N.C., E.M., J.C.-M., I.F.-C.).
Stroke Pharmacogenomics and Genetics, Sant Pau Institute of Research, Sant Pau Hospital, Barcelona, Spain (N.C., N.P.T.-A., E.M., J.C.-M.).

Francisco Moniche (F)

Department of Neurology, Hospital Universitario Virgen del Rocio, Sevilla, Spain (F.M., J.A.C.).

Juan A Cabezas (JA)

Department of Neurology, Hospital Universitario Virgen del Rocio, Sevilla, Spain (F.M., J.A.C.).

Andria L Ford (AL)

Department of Neurology (L.H., M.M.B., A.L.F., R.D., J.-M.L.), Washington University School of Medicine, St Louis, MO.

Rajat Dhar (R)

Department of Neurology (L.H., M.M.B., A.L.F., R.D., J.-M.L.), Washington University School of Medicine, St Louis, MO.

Jaume Roquer (J)

Institut Hospital del Mar d'Investigacions Mediques (IMIM), Barcelona, Spain (L.M.-N., C.S.-T., E.G.-S., J.R., J.J.-C.).
Department of Neurology, Hospital de Mar, Barcelona, Spain (E.G.-S., J.R., J.J.-C.).
Henry and Alison Center for Brain Health, Center for Genomic Medicine, Division of Neurocritical Care and Emergency Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (J.R.).

Pooja Khatri (P)

Department of Neurology, University of Cincinnati, OH (P.K.).

Jordi Jiménez-Conde (J)

Institut Hospital del Mar d'Investigacions Mediques (IMIM), Barcelona, Spain (L.M.-N., C.S.-T., E.G.-S., J.R., J.J.-C.).
Department of Neurology, Hospital de Mar, Barcelona, Spain (E.G.-S., J.R., J.J.-C.).

Israel Fernandez-Cadenas (I)

Neurovascular Research Laboratory and Neurovascular Unit, Vall d'Hebron Institute of Research (VHIR) (C. Carrera, A.B., I.F.-C., J.M.), Universitat Autonoma de Barcelona, Spain.
Department of Neurology, Hospital Mutua de Terrassa, Spain (J.K., I.F.-C.).
Stroke Pharmacogenomics and Genetics, Fundacio Docencia I Recerca Mutua de Terrassa, Spain (N.C., E.M., J.C.-M., I.F.-C.).

Joan Montaner (J)

Neurovascular Research Laboratory and Neurovascular Unit, Vall d'Hebron Institute of Research (VHIR) (C. Carrera, A.B., I.F.-C., J.M.), Universitat Autonoma de Barcelona, Spain.
Institute de Biomedicine of Seville, IBiS/Hospital Universitario Virgen del Rocío/CSIC/University of Seville and Department of Neurology, Hospital Universitario Virgen Macarena (J.M.).

Jonathan Rosand (J)

Institut Hospital del Mar d'Investigacions Mediques (IMIM), Barcelona, Spain (L.M.-N., C.S.-T., E.G.-S., J.R., J.J.-C.).
Department of Neurology, Hospital de Mar, Barcelona, Spain (E.G.-S., J.R., J.J.-C.).
Henry and Alison Center for Brain Health, Center for Genomic Medicine, Division of Neurocritical Care and Emergency Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (J.R.).

Carlos Cruchaga (C)

Department of Psychiatry (L.I., C. Cruchaga), Washington University School of Medicine, St Louis, MO.

Jin-Moo Lee (JM)

Department of Neurology (L.H., M.M.B., A.L.F., R.D., J.-M.L.), Washington University School of Medicine, St Louis, MO.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Early Neurological Change After Ischemic...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Early Neurological Change After Ischemic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Early Neurological Change After Ischemic...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › Accident vasculaire cérébral ischémique › Early Neurological Change After Ischemic...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Early Neurological Change After Ischemic...
questionsmedicales.fr › Phénomènes biologiques › Récupération fonctionnelle › Early Neurological Change After Ischemic...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Acuité des besoins du patient › Indice de gravité de la maladie › Early Neurological Change After Ischemic...