Recombinant Paraprobiotics as a New Paradigm for Treating Gastrointestinal Nematode Parasites of Humans.
Bacillus thuringiensis
anthelmintic
crystal protein
gastrointestinal nematodes
helminths
hookworms
paraprobiotic
soil-transmitted helminths
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
17 02 2021
17 02 2021
Historique:
received:
10
07
2020
accepted:
08
12
2020
pubmed:
16
12
2020
medline:
22
6
2021
entrez:
15
12
2020
Statut:
epublish
Résumé
Gastrointestinal nematodes (GINs) of humans, e.g., hookworms, negatively impact childhood growth, cognition, nutrition, educational attainment, income, productivity, and pregnancy. Hundreds of millions of people are targeted with mass drug administration (MDA) of donated benzimidazole anthelmintics. However, benzimidazole efficacy against GINs is suboptimal, and reduced/low efficacy has been seen. Developing an anthelmintic for human MDA is daunting: it must be safe, effective, inexpensive, stable without a cold chain, and massively scalable.
Identifiants
pubmed: 33318013
pii: AAC.01469-20
doi: 10.1128/AAC.01469-20
pmc: PMC8092541
pii:
doi:
Substances chimiques
Anthelmintics
0
Bacterial Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI056189
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI150866
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI015066
Pays : United States
Informations de copyright
Copyright © 2021 Li et al.
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