Peculiar Phenotypic and Cytotoxic Features of Pulmonary Mucosal CD8 T Cells in People Living with HIV Receiving Long-Term Antiretroviral Therapy.
Adult
Anti-Retroviral Agents
/ therapeutic use
Cell Degranulation
Cells, Cultured
Cellular Senescence
Cytotoxicity, Immunologic
Female
HIV Infections
/ drug therapy
HIV Long-Term Survivors
HIV-1
/ physiology
Humans
Immune Evasion
Immunologic Memory
Immunophenotyping
Lymphocyte Activation
Male
Middle Aged
Phenotype
Respiratory Mucosa
/ immunology
T-Lymphocytes, Cytotoxic
/ immunology
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
01 02 2021
01 02 2021
Historique:
received:
05
08
2020
accepted:
13
11
2020
pubmed:
16
12
2020
medline:
3
8
2021
entrez:
15
12
2020
Statut:
ppublish
Résumé
People living with HIV have high burdens of chronic lung disease, lung cancers, and pulmonary infections despite antiretroviral therapy (ART). The rates of tobacco smoking by people living with HIV vastly exceed that of the general population. Furthermore, we showed that HIV can persist within the lung mucosa despite long-term ART. As CD8 T cell cytotoxicity is pivotal for controlling viral infections and eliminating defective cells, we explored the phenotypic and functional features of pulmonary versus peripheral blood CD8 T cells in ART-treated HIV
Identifiants
pubmed: 33318292
pii: jimmunol.2000916
doi: 10.4049/jimmunol.2000916
doi:
Substances chimiques
Anti-Retroviral Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
641-651Subventions
Organisme : CIHR
ID : 153082
Pays : Canada
Informations de copyright
Copyright © 2021 by The American Association of Immunologists, Inc.