Activation of the NRF2 pathway in Keap1-knockdown mice attenuates progression of age-related hearing loss.
Journal
NPJ aging and mechanisms of disease
ISSN: 2056-3973
Titre abrégé: NPJ Aging Mech Dis
Pays: England
ID NLM: 101678947
Informations de publication
Date de publication:
14 Dec 2020
14 Dec 2020
Historique:
received:
26
03
2020
accepted:
12
11
2020
entrez:
15
12
2020
pubmed:
16
12
2020
medline:
16
12
2020
Statut:
epublish
Résumé
Age-related hearing loss (AHL) is a progressive sensorineural hearing loss in elderly people. Although no prevention or treatments have been established for AHL, recent studies have demonstrated that oxidative stress is closely related to pathogenesis of AHL, suggesting that suppression of oxidative stress leads to inhibition of AHL progression. NRF2 is a master transcription factor that regulates various antioxidant proteins and cytoprotection factors. To examine whether NRF2 pathway activation prevents AHL, we used Keap1-knockdown (Keap1
Identifiants
pubmed: 33318486
doi: 10.1038/s41514-020-00053-4
pii: 10.1038/s41514-020-00053-4
pmc: PMC7736866
doi:
Types de publication
Journal Article
Langues
eng
Pagination
14Subventions
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 18H04794
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 19K07361
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 18K16826
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 18H02949
Organisme : Princess Takamatsu Cancer Research Fund
ID : 15-24728
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : JP20gm5010002
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