Using functional connectivity changes associated with cognitive fatigue to delineate a fatigue network.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
14 12 2020
14 12 2020
Historique:
received:
28
04
2020
accepted:
24
11
2020
entrez:
15
12
2020
pubmed:
16
12
2020
medline:
28
4
2021
Statut:
epublish
Résumé
Cognitive fatigue, or fatigue related to mental work, is a common experience. A growing body of work using functional neuroimaging has identified several regions that appear to be related to cognitive fatigue and that potentially comprise a "fatigue network". These include the striatum of the basal ganglia, the dorsolateral prefrontal cortex (DLPFC), the dorsal anterior cingulate cortex (dACC), the ventro-medial prefrontal cortex (vmPFC) and the anterior insula. However, no work has been conducted to assess whether the connectivity between these regions changes as a function of cognitive fatigue. We used a task-based functional neuroimaging paradigm to induce fatigue in 39 healthy individuals, regressed the signal associated with the task out of the data, and investigated how the functional connectivity between these regions changed as cognitive fatigue increased. We observed functional connectivity between these regions and other frontal regions largely decreased as cognitive fatigue increased while connectivity between these seeds and more posterior regions increased. Furthermore the striatum, the DLPFC, the insula and the vmPFC appeared to be central 'nodes' or hubs of the fatigue network. These findings represent the first demonstration that the functional connectivity between these areas changes as a function of cognitive fatigue.
Identifiants
pubmed: 33318529
doi: 10.1038/s41598-020-78768-3
pii: 10.1038/s41598-020-78768-3
pmc: PMC7736266
doi:
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
21927Subventions
Organisme : CSRD VA
ID : I01 CX000893
Pays : United States
Organisme : VA
ID : 5I01CX000893
Pays : United States
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