Identification of similar epitopes between severe acute respiratory syndrome coronavirus-2 and Bacillus Calmette-Guérin: potential for cross-reactive adaptive immunity.
2019‐nCoV
BCG
Bacillus Calmette–Guérin
COVID‐19
SARS‐CoV‐2
Journal
Clinical & translational immunology
ISSN: 2050-0068
Titre abrégé: Clin Transl Immunology
Pays: Australia
ID NLM: 101638268
Informations de publication
Date de publication:
2020
2020
Historique:
received:
20
06
2020
revised:
20
11
2020
accepted:
22
11
2020
entrez:
15
12
2020
pubmed:
16
12
2020
medline:
16
12
2020
Statut:
epublish
Résumé
Bacillus Calmette-Guérin (BCG) vaccination has been implicated in protection against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and as a non-specific immunisation method against the virus. We therefore decided to investigate T-cell and B-cell epitopes within the BCG-Pasteur strain proteome for similarity to immunogenic peptides of SARS-CoV-2. We used NetMHC 4.0 and BepiPred 2.0 epitope prediction methods for the analysis of the BCG-Pasteur proteome to identify similar peptides to established and novel SARS-CoV-2 T-cell and B-cell epitopes. We found 112 BCG MHC-I-restricted T-cell epitopes similar to MHC-I-restricted T-cell SARS-CoV-2 epitopes and 690 BCG B-cell epitopes similar to SARS-CoV-2 B-cell epitopes. The SARS-CoV-2 T-cell epitopes represented 16 SARS-CoV-2 proteins, and the SARS-CoV-2 B-cell epitopes represented 5 SARS-CoV-2 proteins, including the receptor binding domain of the spike glycoprotein. Altogether, our results provide a mechanistic basis for the potential cross-reactive adaptive immunity that may exist between the two microorganisms.
Identifiants
pubmed: 33318797
doi: 10.1002/cti2.1227
pii: CTI21227
pmc: PMC7724920
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e1227Informations de copyright
© 2020 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Nat Immunol. 2020 Sep 30;:
pubmed: 32999467
Clin Microbiol Infect. 2019 Dec;25(12):1473-1478
pubmed: 31055165
Nucleic Acids Res. 2017 Jul 3;45(W1):W24-W29
pubmed: 28472356
Science. 2020 Oct 2;370(6512):89-94
pubmed: 32753554
Immunology. 2018 Jul;154(3):394-406
pubmed: 29315598
BMJ. 2016 Oct 13;355:i5225
pubmed: 27737830
Biochem Biophys Res Commun. 2020 Oct 10;:
pubmed: 33069360
J Innate Immun. 2014;6(2):152-8
pubmed: 24192057
Bioinformatics. 2016 Feb 15;32(4):511-7
pubmed: 26515819