Therapeutic and Vaccine Options for COVID-19: Status after Six Months of the Disease Outbreak.
Adenosine Monophosphate
/ analogs & derivatives
Alanine
/ analogs & derivatives
Amides
/ therapeutic use
Antiviral Agents
/ pharmacology
COVID-19
/ prevention & control
COVID-19 Vaccines
/ pharmacology
Dexamethasone
/ therapeutic use
Humans
Immunization, Passive
Pyrazines
/ therapeutic use
SARS-CoV-2
/ chemistry
Viral Proteins
/ metabolism
COVID-19 Drug Treatment
COVID-19 Serotherapy
COVID-19
SARS-CoV-2
drug repurposing
therapeutics
vaccines
Journal
SLAS discovery : advancing life sciences R & D
ISSN: 2472-5560
Titre abrégé: SLAS Discov
Pays: United States
ID NLM: 101697563
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
pubmed:
16
12
2020
medline:
11
3
2021
entrez:
15
12
2020
Statut:
ppublish
Résumé
An outbreak of the coronavirus disease 2019 (COVID-19) caused by an infection of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurred in Wuhan, China, in December 2019. This new virus belongs to the group of enveloped RNA beta-coronaviruses. Symptoms may differ in various infected persons, but major presentations include dry cough, nasal congestion, shortness of breath, fever, and general malaise. The disease appears to be more severe in patients above the age of 60 years and those with underlying conditions such as diabetes, cancer, cardiovascular diseases, chronic respiratory disease, and hypertension. There is still no approved vaccine against COVID-19, but more than a hundred are at different stages of development. It is known that the development of new drugs takes a relatively long time, so several known and already-approved drugs are being repurposed for the treatment of this disease. In this review, we explore the therapeutic and vaccine options that are available for COVID-19 6 months after its outbreak. Most noteworthy among the therapeutic options are dexamethasone, remdesivir, Avigan (favipiravir) and convalescent plasma.
Identifiants
pubmed: 33319627
doi: 10.1177/2472555220979579
pmc: PMC8940856
pii: S2472-5552(22)06694-1
doi:
Substances chimiques
Amides
0
Antiviral Agents
0
COVID-19 Vaccines
0
Pyrazines
0
Viral Proteins
0
remdesivir
3QKI37EEHE
Adenosine Monophosphate
415SHH325A
Dexamethasone
7S5I7G3JQL
favipiravir
EW5GL2X7E0
Alanine
OF5P57N2ZX
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
311-329Références
Cell. 2020 Jul 9;182(1):73-84.e16
pubmed: 32425270
Nat Commun. 2020 May 4;11(1):2251
pubmed: 32366817
J Proteome Res. 2020 Nov 6;19(11):4690-4697
pubmed: 32692185
Biochim Biophys Acta Mol Basis Dis. 2020 Oct 1;1866(10):165878
pubmed: 32544429
Biochemistry. 2020 May 12;59(18):1769-1779
pubmed: 32293875
Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16119-24
pubmed: 18852458
bioRxiv. 2020 May 13;:
pubmed: 32511340
Science. 2020 Aug 21;369(6506):1010-1014
pubmed: 32540901
Pharmacol Res. 2020 Jul;157:104854
pubmed: 32360585
Science. 2020 Mar 13;367(6483):1260-1263
pubmed: 32075877
Science. 2020 Aug 28;369(6507):1119-1123
pubmed: 32661058
Emerg Microbes Infect. 2020 Dec;9(1):382-385
pubmed: 32065055
Nature. 2020 Aug;584(7821):437-442
pubmed: 32555388
N Engl J Med. 2021 Feb 11;384(6):497-511
pubmed: 33264556
Antiviral Res. 2020 Jun;178:104786
pubmed: 32251767
JAMA. 2020 Sep 8;324(10):951-960
pubmed: 32789505
Int J Antimicrob Agents. 2020 Aug;56(2):105998
pubmed: 32360231
Antiviral Res. 2017 May;141:101-106
pubmed: 28216367
Hong Kong Med J. 2006 Aug;12(4):294-304
pubmed: 16912357
Nature. 2020 Aug;584(7819):120-124
pubmed: 32454512
Lancet. 2020 Aug 15;396(10249):467-478
pubmed: 32702298
Nature. 2020 Jul;583(7815):290-295
pubmed: 32422645
Trends Immunol. 2020 Nov;41(11):1006-1022
pubmed: 33041212
ACS Cent Sci. 2020 Mar 25;6(3):315-331
pubmed: 32226821
Cell. 2020 May 14;181(4):914-921.e10
pubmed: 32330414
N Engl J Med. 2020 Nov 12;383(20):1920-1931
pubmed: 32663912
Science. 2020 Aug 7;369(6504):650-655
pubmed: 32571838
Virology. 2015 Nov;485:330-9
pubmed: 26331680
ACS Cent Sci. 2020 May 27;6(5):672-683
pubmed: 32483554
Nature. 2020 Aug;584(7821):450-456
pubmed: 32698192
Cell. 2020 Apr 16;181(2):281-292.e6
pubmed: 32155444
Lancet. 2020 Feb 15;395(10223):e30-e31
pubmed: 32032529
Clin Infect Dis. 2020 Nov 5;71(8):1937-1942
pubmed: 32301997
Cell Host Microbe. 2020 Jul 8;28(1):124-133.e4
pubmed: 32485164
J Biol Chem. 2009 Jan 30;284(5):3273-3284
pubmed: 19010777
Science. 2020 Aug 7;369(6504):731-736
pubmed: 32540900
Nat Rev Rheumatol. 2020 Mar;16(3):155-166
pubmed: 32034323
JAMA. 2020 Apr 28;323(16):1582-1589
pubmed: 32219428
Cell. 2020 May 28;181(5):1004-1015.e15
pubmed: 32375025
Science. 2020 Aug 21;369(6506):1014-1018
pubmed: 32540904
J Virol. 2000 Sep;74(17):8127-34
pubmed: 10933723
Nature. 2020 Oct;586(7830):589-593
pubmed: 32785213
Nature. 2020 May;581(7807):221-224
pubmed: 32225175
J Virol. 2011 May;85(9):4122-34
pubmed: 21325420
PLoS Med. 2006 Jul;3(7):e237
pubmed: 16796401
Lancet. 2020 Aug 15;396(10249):479-488
pubmed: 32702299
Nature. 2020 Aug;584(7819):115-119
pubmed: 32454513
Chest. 2020 Jul;158(1):e9-e13
pubmed: 32243945
J Pathol. 2004 Jun;203(2):631-7
pubmed: 15141377
Lancet. 2020 Sep 26;396(10255):887-897
pubmed: 32896291
mBio. 2018 Mar 6;9(2):
pubmed: 29511076
Cell. 2020 Aug 6;182(3):685-712.e19
pubmed: 32645325
Cell Mol Immunol. 2020 Jun;17(6):647-649
pubmed: 32313207
Science. 2020 Aug 21;369(6506):956-963
pubmed: 32540903
Cell Rep. 2020 Jul 21;32(3):107918
pubmed: 32668215
Science. 2003 Jun 13;300(5626):1763-7
pubmed: 12746549
Virol Sin. 2020 Jun;35(3):253-255
pubmed: 32048130
J Virol. 2014 Aug;88(15):8278-96
pubmed: 24829341
Nature. 2020 Jun;582(7813):469
pubmed: 32546811
Antiviral Res. 2015 Apr;116:76-84
pubmed: 25666761
Science. 2020 Jun 12;368(6496):1274-1278
pubmed: 32404477
Science. 2020 Sep 18;369(6510):1505-1509
pubmed: 32703908
Nat Struct Mol Biol. 2020 Oct;27(10):950-958
pubmed: 32737466
J Struct Biol. 2011 Apr;174(1):11-22
pubmed: 21130884
Adv Virus Res. 2019;105:93-116
pubmed: 31522710
Am J Trop Med Hyg. 2019 Jul;101(1):198-206
pubmed: 31074409
Virology. 2003 Jul 20;312(1):25-34
pubmed: 12890618
J Clin Invest. 2020 Apr 1;130(4):1545-1548
pubmed: 32167489
Virol J. 2005 Aug 22;2:69
pubmed: 16115318
Nature. 2020 Aug;584(7821):443-449
pubmed: 32668443
Cell. 2020 Jul 9;182(1):50-58.e8
pubmed: 32516571
Nature. 2020 Oct;586(7830):583-588
pubmed: 32731257
Chembiochem. 2020 Mar 2;21(5):730-738
pubmed: 32022370
Nat Commun. 2020 Jan 10;11(1):222
pubmed: 31924756
Antimicrob Agents Chemother. 2015 Oct 05;60(1):6-13
pubmed: 26438495
J Virol. 2005 Dec;79(24):15189-98
pubmed: 16306590
Nat Commun. 2020 Apr 24;11(1):2070
pubmed: 32332765
Proc Natl Acad Sci U S A. 2020 Apr 28;117(17):9490-9496
pubmed: 32253318
Cell Host Microbe. 2020 Mar 11;27(3):325-328
pubmed: 32035028
Science. 2020 Aug 14;369(6505):812-817
pubmed: 32434946
BMJ. 2020 Jun 8;369:m2263
pubmed: 32513810
JAMA. 2020 Aug 4;324(5):460-470
pubmed: 32492084
Ann Rheum Dis. 2014 Sep;73(9):1626-34
pubmed: 24297381
Immunity. 2020 Jul 14;53(1):98-105.e5
pubmed: 32561270
Methods. 2021 Nov;195:57-71
pubmed: 33453392
N Engl J Med. 2020 Nov 5;383(19):1813-1826
pubmed: 32445440
Infect Dis Poverty. 2020 Apr 28;9(1):45
pubmed: 32345362
Cell Host Microbe. 2020 Jun 10;27(6):891-898.e5
pubmed: 32413276
J Chem Inf Model. 2020 Dec 28;60(12):5754-5770
pubmed: 32551639
Science. 2020 Aug 7;369(6504):643-650
pubmed: 32540902
Front Immunol. 2017 Nov 22;8:1603
pubmed: 29213270
Signal Transduct Target Ther. 2020 Oct 13;5(1):237
pubmed: 33051445
Cell. 2020 Aug 20;182(4):828-842.e16
pubmed: 32645326
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
J Virol. 2004 Nov;78(22):12218-24
pubmed: 15507608
Clin Toxicol (Phila). 2010 Jun;48(5):407-14
pubmed: 20586571
PLoS One. 2018 Nov 16;13(11):e0205743
pubmed: 30444865
Nature. 2020 May;581(7807):215-220
pubmed: 32225176
J Virol. 2008 Sep;82(17):8887-90
pubmed: 18562523
Cell. 2019 Feb 21;176(5):1026-1039.e15
pubmed: 30712865
Drugs. 2009;69(5):609-32
pubmed: 19368420
Adv Virus Res. 2005;64:165-230
pubmed: 16139595
Nature. 2014 Apr 17;508(7496):402-5
pubmed: 24590073
Virology. 2007 Jan 20;357(2):215-27
pubmed: 16979208
Virology. 2015 Apr;478:75-85
pubmed: 25726972
Nature. 2020 Mar;579(7798):265-269
pubmed: 32015508