Epigenome-wide association study and network analysis for IgA Nephropathy from CD19

Case-Control Studies DNA Methylation Epigenesis, Genetic Epigenome Genome-Wide Association Study Glomerulonephritis, IGA / genetics Humans
CpGs IgA nephropathy b cells epigenome-wide association study

Journal

Epigenetics
ISSN: 1559-2308
Titre abrégé: Epigenetics
Pays: United States
ID NLM: 101265293

Informations de publication

Date de publication:
12 2021
Historique:
pubmed: 16 12 2020
medline: 13 1 2022
entrez: 15 12 2020
Statut: ppublish

Résumé

IgA nephropathy (IgAN) is the most common primary glomerular disease in China and worldwide. The proliferation of B cells is known to be associated with both risk and prognosis of IgAN, but the epigenetic mechanism underlying this association is unknown. In this study we carried out the first Epigenome-wide Association Study (EWAS) by using the latest Infinium Methylation EPIC BeadChip on 184 B cell-specific samples (92 case/control pairs) for Chinese IgAN population. After rigorous data normalization and residual batch effect correction, linear mixed effect model was used to detect methylation CpG sites associated with IgAN adjusting for age, gender and smoking. False discovery rate (

Identifiants

DOI: 10.1080/15592294.2020.1861171 PMID: 33319642 PMC: PMC8813080
pubmed: 33319642
doi: 10.1080/15592294.2020.1861171
pmc: PMC8813080
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1283-1294

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Auteurs

Yifei Lin (Y)

Precision Medicine Center, Department of Urology, Medical Device Regulatory Research and Evaluation Center, West China Hospital, Sichuan University, Chengdu, China.
Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
ORCID: 0000-0002-3184-9213

Peiran Yin (P)

Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Zhaozhong Zhu (Z)

Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
ORCID: 0000-0001-5662-1541

Yuan Peng (Y)

Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Ming Li (M)

Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Jun Li (J)

Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

Liming Liang (L)

Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
ORCID: 0000-0001-8261-3174

Xueqing Yu (X)

Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Department of Nephrology, Guangdong Provincial People's Hospital, Guangzhou, China.

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Epigenome-wide association study and network...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Epigenome-wide association study and network...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Epigenome-wide association study and network...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Épigénome › Epigenome-wide association study and network...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Epigenome-wide association study and network...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Glomérulonéphrite à dépôts d'IgA › Epigenome-wide association study and network...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Epigenome-wide association study and network...