Regulation of ST6GAL1 sialyltransferase expression in cancer cells.
ST6GAL1
cancer
gene regulation
sialic acid
Journal
Glycobiology
ISSN: 1460-2423
Titre abrégé: Glycobiology
Pays: England
ID NLM: 9104124
Informations de publication
Date de publication:
03 06 2021
03 06 2021
Historique:
received:
20
04
2020
revised:
07
11
2020
accepted:
25
11
2020
pubmed:
16
12
2020
medline:
17
3
2022
entrez:
15
12
2020
Statut:
ppublish
Résumé
The ST6GAL1 sialyltransferase, which adds α2-6 linked sialic acids to N-glycosylated proteins, is overexpressed in a wide range of human malignancies. Recent studies have established the importance of ST6GAL1 in promoting tumor cell behaviors such as invasion, resistance to cell stress and chemoresistance. Furthermore, ST6GAL1 activity has been implicated in imparting cancer stem cell characteristics. However, despite the burgeoning interest in the role of ST6GAL1 in the phenotypic features of tumor cells, insufficient attention has been paid to the molecular mechanisms responsible for ST6GAL1 upregulation during neoplastic transformation. Evidence suggests that these mechanisms are multifactorial, encompassing genetic, epigenetic, transcriptional and posttranslational regulation. The purpose of this review is to summarize current knowledge regarding the molecular events that drive enriched ST6GAL1 expression in cancer cells.
Identifiants
pubmed: 33320246
pii: 6033741
doi: 10.1093/glycob/cwaa110
pmc: PMC8176773
doi:
Substances chimiques
Antigens, CD
0
Sialyltransferases
EC 2.4.99.-
ST6GAL1 protein, human
EC 2.4.99.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
530-539Subventions
Organisme : NCI NIH HHS
ID : R01 CA225177
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008111
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA233581
Pays : United States
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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