Inhibitory Effects of Isobavachalcone on Tau Protein Aggregation, Tau Phosphorylation, and Oligomeric Tau-Induced Apoptosis.

Alzheimer Disease / drug therapy Apoptosis Chalcones Humans Phosphorylation Protein Aggregates tau Proteins / metabolism
Tau protein apoptosis compound−protein interaction isobavachalcone protein aggregation

Journal

ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337

Informations de publication

Date de publication:
06 01 2021
Historique:
pubmed: 16 12 2020
medline: 22 6 2021
entrez: 15 12 2020
Statut: ppublish

Résumé

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases without any effective medicine treatments. The neurofibrillary tangles containing hyperphosphorylated tau protein are one important pathological characteristic. Thus, one practicable strategy for AD drug design is to discover compounds that could inhibit tau protein aggregation and/or phosphorylation. In this study, isobavachalcone, a natural plant-derived compound, has been shown to inhibit tau protein aggregation and disaggregate tau fibrils

Identifiants

DOI: 10.1021/acschemneuro.0c00617 PMID: 33320518
pubmed: 33320518
doi: 10.1021/acschemneuro.0c00617
doi:

Substances chimiques

Chalcones 0
Protein Aggregates 0
tau Proteins 0
isobavachalcone 20784-50-3

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

123-132

Auteurs

Shifeng Xiao (S)

Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong 518060, China.
Shenzhen Bay Laboratory, Shenzhen, Guangdong 518055, China.
ORCID: 0000-0002-4753-6756

Qiuping Wu (Q)

Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong 518060, China.

Xuanbao Yao (X)

Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong 518060, China.

Jiahao Zhang (J)

Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong 518060, China.

Weicong Zhong (W)

Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong 518060, China.

Junyi Zhao (J)

Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong 518060, China.

Qiong Liu (Q)

Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong 518060, China.
ORCID: 0000-0002-6431-3650

Mohan Zhang (M)

Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong 518060, China.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Inhibitory Effects of Isobavachalcone on Tau...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Inhibitory Effects of Isobavachalcone on Tau...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Chalcones › Inhibitory Effects of Isobavachalcone on Tau...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Inhibitory Effects of Isobavachalcone on Tau...
questionsmedicales.fr › Métabolisme › Phosphorylation › Inhibitory Effects of Isobavachalcone on Tau...
questionsmedicales.fr › Structures macromoléculaires › Agrégats de protéines › Inhibitory Effects of Isobavachalcone on Tau...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines associées aux microtubules › Protéines tau › Inhibitory Effects of Isobavachalcone on Tau...