Resveratrol-Based Multivitamin Supplement Increases Sperm Concentration and Motility in Idiopathic Male Infertility: A Pilot Clinical Study.
male infertility
mitochondrial activity
resveratrol
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
11 Dec 2020
11 Dec 2020
Historique:
received:
08
11
2020
revised:
06
12
2020
accepted:
07
12
2020
entrez:
16
12
2020
pubmed:
17
12
2020
medline:
17
12
2020
Statut:
epublish
Résumé
It is known that a multitude of factors may lead to male factor infertility, but still, in the majority of cases, the cause remains largely idiopathic, reflecting poor understanding of the basic process of spermatogenesis and the mechanisms involved. Resveratrol is a polyphenol compound that displays several cellular aspects mainly associated with SIRT1-pathway activation and promotion of mitochondrial enhancer activities. In several animal models, resveratrol has shown positive effects on mitochondria and membrane potential. This could explain effects on sperm concentration and motility. The aim of this study is to evaluate the effects on the semen parameters of GENANTE This was a prospective single center clinical study. Twenty patients took a multivitamin supplement based on 150 mg of resveratrol (GENANTE Our preliminary pilot study demonstrated that the multivitamin supplement based on resveratrol improves sperm motility (48.3% ± 13.8 vs. 59.0% ± 12.8, Our data suggest that targeting the metabolic and energetic pathways involved in spermatogenesis and mitochondrial activity could lead to potential effects and counteract subfertility/infertility in men through a mitochondria dynamics mechanism. ClinicalTrials.gov registration identifier: NCT03864198, registered on 1 January 2019.
Sections du résumé
BACKGROUND
BACKGROUND
It is known that a multitude of factors may lead to male factor infertility, but still, in the majority of cases, the cause remains largely idiopathic, reflecting poor understanding of the basic process of spermatogenesis and the mechanisms involved. Resveratrol is a polyphenol compound that displays several cellular aspects mainly associated with SIRT1-pathway activation and promotion of mitochondrial enhancer activities. In several animal models, resveratrol has shown positive effects on mitochondria and membrane potential. This could explain effects on sperm concentration and motility. The aim of this study is to evaluate the effects on the semen parameters of GENANTE
METHODS
METHODS
This was a prospective single center clinical study. Twenty patients took a multivitamin supplement based on 150 mg of resveratrol (GENANTE
RESULTS
RESULTS
Our preliminary pilot study demonstrated that the multivitamin supplement based on resveratrol improves sperm motility (48.3% ± 13.8 vs. 59.0% ± 12.8,
CONCLUSION
CONCLUSIONS
Our data suggest that targeting the metabolic and energetic pathways involved in spermatogenesis and mitochondrial activity could lead to potential effects and counteract subfertility/infertility in men through a mitochondria dynamics mechanism.
TRIAL REGISTRATION NUMBER
BACKGROUND
ClinicalTrials.gov registration identifier: NCT03864198, registered on 1 January 2019.
Identifiants
pubmed: 33322606
pii: jcm9124017
doi: 10.3390/jcm9124017
pmc: PMC7763587
pii:
doi:
Banques de données
ClinicalTrials.gov
['NCT03864198']
Types de publication
Journal Article
Langues
eng
Déclaration de conflit d'intérêts
The authors declare that they have no conflict of interests.
Références
Hum Reprod Update. 2017 Nov 1;23(6):660-680
pubmed: 28981651
Asian J Androl. 2020 Apr 28;:
pubmed: 32341213
Cell Mol Life Sci. 2020 Jan;77(1):93-113
pubmed: 31377843
Biochim Biophys Acta. 1984 Nov 26;767(2):248-56
pubmed: 6498180
Mitochondrion. 2010 Aug;10(5):419-28
pubmed: 20595008
Fertil Steril. 2007 Feb;87(2):436-8
pubmed: 17074334
Horm Metab Res. 2000 Mar;32(3):87-90
pubmed: 10786925
Asian J Androl. 2002 Jun;4(2):97-103
pubmed: 12085099
Hum Reprod. 1995 Jan;10(1):116-9
pubmed: 7745038
Andrologia. 2020 May;52(4):e13556
pubmed: 32129519
Asian J Androl. 2019 Jul-Aug;21(4):400-407
pubmed: 30618415
Reproduction. 2013 Oct 01;146(5):R163-74
pubmed: 23901129
J Clin Med. 2019 Apr 25;8(4):
pubmed: 31027257
Hum Reprod Update. 2008 May-Jun;14(3):243-58
pubmed: 18281241
Hum Fertil (Camb). 2010 Dec;13(4):217-25
pubmed: 21117931
Asian J Androl. 2013 Mar;15(2):169-73
pubmed: 23291862
Int J Androl. 2011 Oct;34(5 Pt 2):e330-47
pubmed: 21696400
Fertil Steril. 1996 May;65(5):1009-14
pubmed: 8612826
Reprod Biomed Online. 2009 Nov;19(5):638-59
pubmed: 20021713
J Nutr. 2005 Apr;135(4):757-60
pubmed: 15795430
Arab J Urol. 2018 Feb 13;16(1):10-20
pubmed: 29713532
Curr Med Chem. 2016;23(11):1084-99
pubmed: 26923678
Andrologia. 1997 May-Jun;29(3):125-31
pubmed: 9197915
Mol Hum Reprod. 1998 Jul;4(7):657-66
pubmed: 9701788
Asian J Androl. 2011 Nov;13(6):856-61
pubmed: 21857689
Clin Chem. 1998 Aug;44(8 Pt 1):1616-20
pubmed: 9702947
Arch Pharm Res. 2008 Jan;31(1):83-7
pubmed: 18277612
Nutrients. 2018 Dec 05;10(12):
pubmed: 30563110
Transl Androl Urol. 2019 Dec;8(6):678-685
pubmed: 32038964
Eur Urol. 2012 Aug;62(2):324-32
pubmed: 22591628
Urol Clin North Am. 2014 Feb;41(1):195-204
pubmed: 24286777
J Hum Reprod Sci. 2019 Oct-Dec;12(4):287-293
pubmed: 32038077
Andrologia. 2003 Oct;35(5):325-30
pubmed: 14535865
Hum Reprod Update. 2007 Mar-Apr;13(2):163-74
pubmed: 17099205
J Clin Endocrinol Metab. 2011 May;96(5):1409-14
pubmed: 21289251
Cell Metab. 2012 May 2;15(5):675-90
pubmed: 22560220
Clin Chim Acta. 2000 Oct;300(1-2):97-105
pubmed: 10958866
Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15148-53
pubmed: 17005726
Cent European J Urol. 2019;72(3):324-329
pubmed: 31720038
Fertil Steril. 2011 Feb;95(2):641-6
pubmed: 20840880
Semin Cell Dev Biol. 2016 Nov;59:10-26
pubmed: 27143445
Apoptosis. 2017 Oct;22(10):1260-1272
pubmed: 28755171
Indian J Med Res. 2018 Dec;148(Suppl):S84-S91
pubmed: 30964084
BMJ. 1992 Sep 12;305(6854):609-13
pubmed: 1393072
Hum Reprod. 2008 Apr;23(4):783-91
pubmed: 18281682
Andrology. 2020 Mar;8(2):323-331
pubmed: 31380611
Biochem J. 2007 May 15;404(1):1-13
pubmed: 17447894
Andrologia. 2019 Sep;51(8):e13313
pubmed: 31179568
J Reprod Dev. 2014 Apr 24;60(2):92-9
pubmed: 24390595