Ketone- and Cyano-Selenoesters to Overcome Efflux Pump, Quorum-Sensing, and Biofilm-Mediated Resistance.
Pseudomonas aeruginosa
Salmonella species
Staphylococcus aureus
antibacterial activity
biofilm
multidrug resistance
quorum sensing
selenoesters
Journal
Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404
Informations de publication
Date de publication:
11 Dec 2020
11 Dec 2020
Historique:
received:
12
11
2020
revised:
02
12
2020
accepted:
10
12
2020
entrez:
16
12
2020
pubmed:
17
12
2020
medline:
17
12
2020
Statut:
epublish
Résumé
The emergence of drug-resistant pathogens leads to a gradual decline in the efficacy of many antibacterial agents, which poses a serious problem for proper therapy. Multidrug resistance (MDR) mechanisms allow resistant bacteria to have limited uptake of drugs, modification of their target molecules, drug inactivation, or release of the drug into the extracellular space by efflux pumps (EPs). In previous studies, selenoesters have proved to be promising derivatives with a noteworthy antimicrobial activity. On the basis of these results, two series of novel selenoesters were synthesized to achieve more potent antibacterial activity on Gram-positive and Gram-negative bacteria. Fifteen selenoesters (eight ketone-selenoesters and seven cyano-selenoesters) were investigated with regards to their efflux pump-inhibiting, anti-quorum-sensing (QS), and anti-biofilm effects
Identifiants
pubmed: 33322639
pii: antibiotics9120896
doi: 10.3390/antibiotics9120896
pmc: PMC7763688
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : University of Szeged
ID : SZTE ÁOK-KKA 2018/270-62-2
Organisme : EU, Hungary
ID : GINOP-2.3.2-15-2016-00038
Organisme : Czech Ministry of Education, Youth and Sports
ID : INTER-COST LTC19007
Organisme : EU
ID : COST Action CA17104 STRATAGEM
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