The mRNA Distribution of Cancer Stem Cell Marker CD90/Thy-1 Is Comparable in Hepatocellular Carcinoma of Eastern and Western Populations.
Aged
Biomarkers, Tumor
/ genetics
Carcinoma, Hepatocellular
/ genetics
Cohort Studies
Female
Gene Expression Regulation, Neoplastic
Hepatitis B
/ complications
Humans
Liver Neoplasms
/ genetics
Male
Middle Aged
Neoplastic Stem Cells
/ metabolism
Prognosis
RNA, Messenger
/ genetics
Thy-1 Antigens
/ genetics
cancer stem cells
hepatocellular carcinoma
mRNA expression
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
12 12 2020
12 12 2020
Historique:
received:
26
11
2020
revised:
07
12
2020
accepted:
10
12
2020
entrez:
16
12
2020
pubmed:
17
12
2020
medline:
22
6
2021
Statut:
epublish
Résumé
Epidemiology of hepatocellular carcinoma (HCC) showed a correlation between incidence and geographical-relevant risk factors. This study aims to compare the distributions of cancer stem cells (CSC) in two distant populations in Asia and Europe. We analyzed 52 and 43 selected HCC patients undergoing hepatectomy in Ho Chi Minh City (Vietnam) and Trieste (Italy). Each patient sample consisted of HCC, peri-HCC, and non-tumoral (distal) tissue. Demographic data were recorded together with clinical findings. The protocol for the collection of tissue samples and RNA was standardized in both laboratories and gene expression analysis was performed in a single laboratory with identical PCR conditions. Baseline data showed comparable laboratory findings between the two cohorts. mRNA distribution showed a comparable pattern of all CSC markers analyzed with the expression of CD90 progressively increasing from distal and peri-HCC to be highest in HCC (
Identifiants
pubmed: 33322687
pii: cells9122672
doi: 10.3390/cells9122672
pmc: PMC7764111
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
RNA, Messenger
0
Thy-1 Antigens
0
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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