Glia-Selective Deletion of Complement
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
01 04 2021
01 04 2021
Historique:
received:
01
08
2020
revised:
10
11
2020
accepted:
07
12
2020
pubmed:
17
12
2020
medline:
3
8
2021
entrez:
16
12
2020
Statut:
ppublish
Résumé
The adverse neurocognitive sequelae following clinical radiotherapy (RT) for central nervous system (CNS) malignancies are often long-lasting without any clinical recourse. Despite recent progress, the cellular mechanisms mediating RT-induced cognitive deficits (RICD) are poorly understood. The complement system is an immediate sensor of a disturbed inflammatory environment and a potent mediator of gliosis with a range of nonimmune functions in the CNS, including synaptic pruning, which is detrimental if dysregulated. We hypothesize that complement-mediated changes in glial cell function significantly contribute to RICD. The underlying alterations in CNS complement cascade proteins (C1q, C3), TLR4, and colabeling with glia (IBA1, GFAP) were examined using gene expression, immunofluorescence, and
Identifiants
pubmed: 33323383
pii: 0008-5472.CAN-20-2565
doi: 10.1158/0008-5472.CAN-20-2565
pmc: PMC8137520
mid: NIHMS1654842
doi:
Substances chimiques
Complement C1q
80295-33-6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
1732-1744Subventions
Organisme : NCI NIH HHS
ID : P30 CA062203
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG060148
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentOn
Informations de copyright
©2020 American Association for Cancer Research.
Références
Blood. 2007 Jul 1;110(1):228-36
pubmed: 17363730
J Immunol. 2020 Jan 15;204(2):306-315
pubmed: 31907273
Sci Rep. 2019 Dec 11;9(1):18899
pubmed: 31827187
Radiat Res. 2009 Jan;171(1):66-76
pubmed: 19138045
J Neurosci. 2011 Jul 20;31(29):10721-31
pubmed: 21775615
Acta Neuropathol Commun. 2019 Nov 21;7(1):186
pubmed: 31753024
Br J Cancer. 2000 Jan;82(2):255-62
pubmed: 10646874
Sci Rep. 2016 Aug 12;6:31545
pubmed: 27516055
J Neurosci. 2015 Sep 23;35(38):13029-42
pubmed: 26400934
Neurobiol Aging. 2014 Dec;35(12):2746-2760
pubmed: 25002035
Glia. 2019 Jul;67(7):1359-1373
pubmed: 30882931
Int J Radiat Oncol Biol Phys. 2006 Nov 1;66(3):860-6
pubmed: 17011458
J Neuroinflammation. 2015 Jun 06;12:114
pubmed: 26048578
Cancer Res. 2003 Jul 15;63(14):4021-7
pubmed: 12874001
Mol Immunol. 2018 Oct;102:3-13
pubmed: 29958698
Nature. 2016 Jun 22;534(7608):538-43
pubmed: 27337340
J Neuroinflammation. 2017 Mar 6;14(1):48
pubmed: 28264694
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4069-74
pubmed: 23431168
Nat Commun. 2020 Jul 27;11(1):3753
pubmed: 32719333
Hum Genomics. 2013 Oct 30;7:22
pubmed: 24172014
Nature. 2017 Jan 26;541(7638):481-487
pubmed: 28099414
Radiat Res. 2020 Dec 1;194(6):636-645
pubmed: 32853387
Cell Rep. 2019 Aug 20;28(8):2111-2123.e6
pubmed: 31433986
Acta Neuropathol Commun. 2014 May 09;2:53
pubmed: 24887075
Int J Radiat Biol. 1997 Jul;72(1):45-53
pubmed: 9246193
Oncotarget. 2016 Apr 12;7(15):19382-94
pubmed: 27029069
Science. 2016 May 6;352(6286):712-716
pubmed: 27033548
Mol Cancer Res. 2010 Nov;8(11):1453-65
pubmed: 20870736
Brain Behav Immun. 2017 Jan;59:313-321
pubmed: 27562421
J Neurosci. 2007 Mar 14;27(11):2948-57
pubmed: 17360918
Nat Immunol. 2008 Nov;9(11):1225-35
pubmed: 18820683
Brain Behav Immun. 2010 Feb;24(2):243-53
pubmed: 19825412
Cancer Med. 2014 Aug;3(4):747-58
pubmed: 24711204
Physiol Rev. 2014 Oct;94(4):1077-98
pubmed: 25287860
Free Radic Biol Med. 2010 Dec 15;49(12):1846-55
pubmed: 20826207
Neurobiol Dis. 2016 Dec;96:84-94
pubmed: 27544484
Front Mol Neurosci. 2016 Jun 03;9:42
pubmed: 27375429
Front Oncol. 2012 Jul 19;2:73
pubmed: 22833841
Cancer Res. 2013 Feb 1;73(3):1201-10
pubmed: 23243025
Cancer Res. 2020 Oct 1;80(19):4266-4277
pubmed: 32816912
J Neuroinflammation. 2016 Aug 30;13(1):215
pubmed: 27576527
Cell. 2007 Dec 14;131(6):1164-78
pubmed: 18083105
J Clin Oncol. 2006 Mar 10;24(8):1305-9
pubmed: 16525186
Radiat Res. 2011 Oct;176(4):459-73
pubmed: 21787181
Mol Neurodegener. 2017 Sep 18;12(1):66
pubmed: 28923083
Proc Natl Acad Sci U S A. 2019 May 28;116(22):10943-10951
pubmed: 31097580
Int J Radiat Oncol Biol Phys. 1995 Aug 30;33(1):233-4
pubmed: 7642425
J Neurochem. 2008 Sep;106(5):2080-92
pubmed: 18624920
Semin Radiat Oncol. 2009 Apr;19(2):122-32
pubmed: 19249650
Neuron. 2014 Feb 19;81(4):728-39
pubmed: 24559669
Radiat Res. 2004 Jul;162(1):39-47
pubmed: 15222778
Brain Behav Immun. 2018 Feb;68:34-43
pubmed: 28943292
Acta Neuropathol Commun. 2018 Sep 12;6(1):91
pubmed: 30208949
eNeuro. 2019 Aug 22;6(4):
pubmed: 31383727
J Cell Biol. 2015 Nov 9;211(3):619-37
pubmed: 26553931
Science. 2020 Feb 7;367(6478):688-694
pubmed: 32029629
Transl Cancer Res. 2014 Apr 1;3(2):124-137
pubmed: 24904783
Lancet Oncol. 2011 Jul;12(7):703-8
pubmed: 21354373
Neurobiol Dis. 2006 Jul;23(1):127-39
pubmed: 16697651
J Neuroinflammation. 2020 May 19;17(1):159
pubmed: 32429943
Neurobiol Dis. 2007 Jun;26(3):497-511
pubmed: 17412602
Neuropharmacology. 2009 Sep;57(4):343-6
pubmed: 19577581