Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study.

Blood Glucose Cholesterol, HDL Diabetes Mellitus, Type 2 Humans Insulin Insulin Resistance Insulin-Secreting Cells

Journal

Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975

Informations de publication

Date de publication:
02 2021
Historique:
received: 24 06 2020
accepted: 31 10 2020
pubmed: 17 12 2020
medline: 21 8 2021
entrez: 16 12 2020
Statut: ppublish

Résumé

We investigated the processes underlying glycemic deterioration in type 2 diabetes (T2D). A total of 732 recently diagnosed patients with T2D from the Innovative Medicines Initiative Diabetes Research on Patient Stratification (IMI DIRECT) study were extensively phenotyped over 3 years, including measures of insulin sensitivity (OGIS), β-cell glucose sensitivity (GS), and insulin clearance (CLIm) from mixed meal tests, liver enzymes, lipid profiles, and baseline regional fat from MRI. The associations between the longitudinal metabolic patterns and HbA Faster HbA Deteriorating insulin sensitivity and β-cell function, increasing insulin clearance, high visceral or liver fat, and worsening of the lipid profile are the crucial factors mediating glycemic deterioration of patients with T2D in the initial phase of the disease. Stabilization of a single trait among insulin sensitivity, β-cell function, and insulin clearance may be relevant to prevent progression.

Identifiants

DOI: 10.2337/dc20-1567 PMID: 33323478
pubmed: 33323478
pii: dc20-1567
doi: 10.2337/dc20-1567
doi:

Substances chimiques

Blood Glucose 0
Cholesterol, HDL 0
Insulin 0

Banques de données

figshare
['10.2337/figshare.13222205']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

511-518

Subventions

Organisme : Medical Research Council
ID : MC_UU_00006/4
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12015/3
Pays : United Kingdom

Investigateurs

Moustafa Abdalla (M)
Jonathan Adam (J)
Jerzy Adamski (J)
Kofi Adragni (K)
Rosa L Allesøe (RL)
Kristine H Allin (KH)
Manimozhiyan Arumugam (M)
Naeimeh Atabaki Pasdar (N)
Tania Baltauss (T)
Karina Banasik (K)
Patrick Baum (P)
Jimmy D Bell (JD)
Margit Bergstrom (M)
Joline W Beulens (JW)
Susanna Bianzano (S)
Roberto Bizzotto (R)
Amelie Bonneford (A)
Caroline A Brorsson (CA)
Andrew A Brown (AA)
Søren Brunak (S)
Louise Cabrelli (L)
Robert Caiazzo (R)
Mickaël Canouil (M)
Matilda Dale (M)
David Davtian (D)
Adem Y Dawed (AY)
Federico De Masi (F)
Nathalie de Preville (N)
Koen F Dekkers (KF)
Emmanouil T Dermitzakis (ET)
Harshal A Deshmukh (HA)
Christiane Dings (C)
Louise Donnelly (L)
Avirup Dutta (A)
Beate Ehrhardt (B)
Petra Elders (P)
Line Engelbrechtsen (L)
Rebeca Eriksen (R)
Juan Fernandez (J)
Jorge Ferrer (J)
Hugo Fitipaldi (H)
Ian M Forgie (IM)
Annemette Forman (A)
Paul W Franks (PW)
Francesca Frau (F)
Andreas Fritsche (A)
Philippe Froguel (P)
Gary Frost (G)
Johann Gassenhuber (J)
Nick N Giordano (NN)
Toni Giorgino (T)
Stephen Gough (S)
Ulrike U Graefe-Mody (UU)
Harald Grallert (H)
Rolf Grempler (R)
Lenka Groeneveld (L)
Leif Groop (L)
Valborg Gudmundsdóttir (V)
Mark Haid (M)
Torben Hansen (T)
Tue H Hansen (TH)
Andrew T Hattersley (AT)
Ragna Haussler (R)
Alison J Heggie (AJ)
Anita M Hennige (AM)
Anita V Hill (AV)
Reinhard W Holl (RW)
Mun-Gwan Hong (MG)
Michelle Hudson (M)
Bernd Jablonka (B)
Christopher Jennison (C)
Yunlong Jiao (Y)
Joachim Johansen (J)
Angus G Jones (AG)
Anna Jonsson (A)
Tugce Karaderi (T)
Jane Kaye (J)
Maria Klintenberg (M)
Robert W Koivula (RW)
Tarja Kokkola (T)
Anitra D Koopman (AD)
Azra Kurbasic (A)
Teemu Kuulasmaa (T)
Markku Laakso (M)
Thorsten Lehr (T)
Heather Loftus (H)
Agnete T Lundgaard (AT)
Anubha Mahajan (A)
Andrea Mari (A)
Gianluca Mazzoni (G)
Mark I McCarthy (MI)
Timothy J McDonald (TJ)
Donna McEvoy (D)
Nicky McRobert (N)
Ian McVittie (I)
Miranda Mourby (M)
Petra B Musholt (PB)
Pascal Mutie (P)
Rachel Nice (R)
Claudia Nicolay (C)
Agnes M Nielsen (AM)
Birgitte Nilsson (B)
Colin N Palmer (CN)
Francois Pattou (F)
Imre Pavo (I)
Ewan R Pearson (ER)
Helle K Pedersen (HK)
Oluf Pedersen (O)
Mandy H Perry (MH)
Hugo Pomares-Millan (H)
Simon Rasmussen (S)
Violeta Raverdy (V)
Martin Ridderstrale (M)
Neil Robertson (N)
Slieker C Roderick (SC)
Marianne Rodriquez (M)
Hartmut Ruetten (H)
Femke Rutters (F)
Peter W Sackett (PW)
Nina Scherer (N)
Jochen M Schwenk (JM)
Nisha Shah (N)
Sapna Sharma (S)
Iryna Sihinevich (I)
Nadja B Sondertoft (NB)
Hans-Henrik Staerfeldt (HH)
Birgit Steckel-Hamann (B)
Leen M T Hart (LM)
Harriet Teare (H)
Cecilia E Thomas (CE)
Melissa K Thomas (MK)
Elizabeth L Thomas (EL)
Henrik S Thomsen (HS)
Barbara Thorand (B)
Claire E Thorne (CE)
Joachim Tillner (J)
Martina Troll (M)
Konstantinos D Tsirigos (KD)
Andrea Tura (A)
Mathias Uhlen (M)
Nienke van Leeuwen (N)
Helene Verkindt (H)
Henrik Vestergaard (H)
Ana Viñuela (A)
Josef K Vogt (JK)
Dianne Wake (D)
Mark Walker (M)
Agata Wesolowska-Andersen (A)
Brandon Whitcher (B)
Han Wu (H)

Informations de copyright

© 2020 by the American Diabetes Association.

Auteurs

Roberto Bizzotto (R)

CNR Institute of Neuroscience, Padova, Italy roberto.bizzotto@cnr.it.
ORCID: 0000-0002-8251-1730

Christopher Jennison (C)

Department of Mathematical Sciences, University of Bath, Bath, U.K.

Angus G Jones (AG)

Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, U.K.
Diabetes and Endocrinology, Royal Devon and Exeter NHS Foundation Trust, Exeter, U.K.
ORCID: 0000-0002-0883-7599

Azra Kurbasic (A)

Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre, Lund University, Skåne University Hospital, Malmö, Malmö, Sweden.

Andrea Tura (A)

CNR Institute of Neuroscience, Padova, Italy.

Gwen Kennedy (G)

Immunoassay Biomarker Core Laboratory, School of Medicine, Ninewells Hospital, Dundee, U.K.

Jimmy D Bell (JD)

School of Life Sciences, Research Centre for Optimal Health, University of Westminster, London, U.K.

E Louise Thomas (EL)

School of Life Sciences, Research Centre for Optimal Health, University of Westminster, London, U.K.

Gary Frost (G)

Section for Nutrition Research, Faculty of Medicine, Hammersmith Campus, Imperial College London, London, U.K.
ORCID: 0000-0003-0529-6325

Rebeca Eriksen (R)

Section for Nutrition Research, Faculty of Medicine, Hammersmith Campus, Imperial College London, London, U.K.

Robert W Koivula (RW)

Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre, Lund University, Skåne University Hospital, Malmö, Malmö, Sweden.
Radcliffe Department of Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, U.K.
ORCID: 0000-0002-1646-4163

Soren Brage (S)

MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K.

Jane Kaye (J)

Faculty of Law, Centre for Health, Law and Emerging Technologies, University of Oxford, Oxford, U.K.
Melbourne Law School, Centre for Health, Law and Emerging Technologies, University of Melbourne, Carlton, Victoria, Australia.

Andrew T Hattersley (AT)

Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, U.K.
Diabetes and Endocrinology, Royal Devon and Exeter NHS Foundation Trust, Exeter, U.K.
ORCID: 0000-0001-5620-473X

Alison Heggie (A)

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, U.K.

Donna McEvoy (D)

Diabetes Research Network, Royal Victoria Infirmary, Newcastle upon Tyne, U.K.

Leen M 't Hart (LM)

Department of Epidemiology and Data Science, Amsterdam UMC-Location VUmc, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.
Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
Department of Biomedical Data Sciences, Molecular Epidemiology Section, Leiden University Medical Center, Leiden, the Netherlands.

Joline W Beulens (JW)

Department of Epidemiology and Data Science, Amsterdam UMC-Location VUmc, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.
ORCID: 0000-0002-4181-0937

Petra Elders (P)

Department of General Practice, Amsterdam UMC-Location VUmc, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.

Petra B Musholt (PB)

R&D Global Development, Translational Medicine & Clinical Pharmacology, Sanofi Deutschland GmbH, Frankfurt, Germany.

Martin Ridderstråle (M)

Clinical Pharmacology and Translational Medicine, Novo Nordisk A/S, Søborg, Denmark.
ORCID: 0000-0002-3270-9167

Tue H Hansen (TH)

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Kristine H Allin (KH)

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
ORCID: 0000-0002-6880-5759

Torben Hansen (T)

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
ORCID: 0000-0001-8748-3831

Henrik Vestergaard (H)

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Bornholms Hospital, Rønne, Denmark.

Agnete T Lundgaard (AT)

Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.
Department of Systems Biology, Center for Biological Sequence Analysis, Technical University of Denmark, Kongens Lyngby, Denmark.

Henrik S Thomsen (HS)

Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark.

Federico De Masi (F)

Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.

Konstantinos D Tsirigos (KD)

Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.
Department of Systems Biology, Center for Biological Sequence Analysis, Technical University of Denmark, Kongens Lyngby, Denmark.

Søren Brunak (S)

Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.
Department of Systems Biology, Center for Biological Sequence Analysis, Technical University of Denmark, Kongens Lyngby, Denmark.

Ana Viñuela (A)

Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.
Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle, U.K.

Anubha Mahajan (A)

Wellcome Centre for Human Genetics, University of Oxford, Oxford, U.K.
ORCID: 0000-0001-5585-3420

Timothy J McDonald (TJ)

Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, U.K.
Blood Sciences, Royal Devon and Exeter NHS Foundation Trust, Exeter, U.K.
ORCID: 0000-0003-3559-6660

Tarja Kokkola (T)

Department of Medicine, University of Eastern Finland, Kuopio, Finland.

Ian M Forgie (IM)

Population Health and Genomics, School of Medicine, University of Dundee, Dundee, U.K.

Giuseppe N Giordano (GN)

Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre, Lund University, Skåne University Hospital, Malmö, Malmö, Sweden.

Imre Pavo (I)

Eli Lilly Regional Operations GmbH, Vienna, Austria.

Hartmut Ruetten (H)

R&D Global Development, Translational Medicine & Clinical Pharmacology, Sanofi Deutschland GmbH, Frankfurt, Germany.

Emmanouil Dermitzakis (E)

Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.

Mark I McCarthy (MI)

Radcliffe Department of Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, U.K.
Wellcome Centre for Human Genetics, University of Oxford, Oxford, U.K.
Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, U.K.

Oluf Pedersen (O)

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Jochen M Schwenk (JM)

Affinity Proteomics, Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Solna, Sweden.

Jerzy Adamski (J)

Research Unit of Molecular Endocrinology and Metabolism, Helmholtz Zentrum München, Neuherberg, Germany.
Lehrstuhl für Experimentelle Genetik, Technische Universität München, Freising-Weihenstephan, Germany.
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Paul W Franks (PW)

Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre, Lund University, Skåne University Hospital, Malmö, Malmö, Sweden.
ORCID: 0000-0002-0520-7604

Mark Walker (M)

Faculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle, U.K.

Ewan R Pearson (ER)

Population Health and Genomics, School of Medicine, University of Dundee, Dundee, U.K.
ORCID: 0000-0001-9237-8585

Andrea Mari (A)

ORCID: 0000-0002-1436-5591

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Classifications MeSH

questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Glycémie › Processes Underlying Glycemic Deterioration in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Lipoprotéines HDL › Cholestérol HDL › Processes Underlying Glycemic Deterioration in...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Processes Underlying Glycemic Deterioration in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Processes Underlying Glycemic Deterioration in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › Processes Underlying Glycemic Deterioration in...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Insulinorésistance › Processes Underlying Glycemic Deterioration in...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules entéroendocrines › Cellules à insuline › Processes Underlying Glycemic Deterioration in...