A Noncanonical DNA Damage Checkpoint Response in a Major Fungal Pathogen.

Cell Cycle Checkpoints Cell Division Checkpoint Kinase 2 / genetics DNA Damage Fungal Proteins / genetics Gene Expression Regulation, Fungal Humans Mycoses / microbiology Phosphorylation S Phase Saccharomyces cerevisiae / cytology Saccharomycetales / cytology
Candida glabrata DNA damage checkpoints DNA damage response Rad53 cell division

Journal

mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231

Informations de publication

Date de publication:
15 12 2020
Historique:
entrez: 16 12 2020
pubmed: 17 12 2020
medline: 3 9 2021
Statut: epublish

Résumé

DNA damage checkpoints are key guardians of genome integrity. Eukaryotic cells respond to DNA damage by triggering extensive phosphorylation of Rad53/CHK2 effector kinase, whereupon activated Rad53/CHK2 mediates further aspects of checkpoint activation, including cell cycle arrest and transcriptional changes. Budding yeast

Identifiants

DOI: 10.1128/mBio.03044-20 PMID: 33323516 PMC: PMC7773997
pubmed: 33323516
pii: mBio.03044-20
doi: 10.1128/mBio.03044-20
pmc: PMC7773997
pii:
doi:

Substances chimiques

Fungal Proteins 0
Checkpoint Kinase 2 EC 2.7.1.11

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NCI NIH HHS
ID : P30 CA051008
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI109025
Pays : United States

Informations de copyright

Copyright © 2020 Shor et al.

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Auteurs

Erika Shor (E)

Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA erika.shor@hmh-cdi.org david.perlin@hmh-cdi.org.
Department of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, New Jersey, USA.
ORCID: 0000-0003-3655-0963

Rocio Garcia-Rubio (R)

Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.

Lucius DeGregorio (L)

Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.

David S Perlin (DS)

Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA erika.shor@hmh-cdi.org david.perlin@hmh-cdi.org.
Department of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, New Jersey, USA.
Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
ORCID: 0000-0002-1268-5524

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Cycle cellulaire › Points de contrôle du cycle cellulaire › A Noncanonical DNA Damage Checkpoint Response...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Division cellulaire › A Noncanonical DNA Damage Checkpoint Response...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Checkpoint kinase 2 › A Noncanonical DNA Damage Checkpoint Response...
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › A Noncanonical DNA Damage Checkpoint Response...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › A Noncanonical DNA Damage Checkpoint Response...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes fongiques › A Noncanonical DNA Damage Checkpoint Response...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A Noncanonical DNA Damage Checkpoint Response...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Mycoses › A Noncanonical DNA Damage Checkpoint Response...
questionsmedicales.fr › Métabolisme › Phosphorylation › A Noncanonical DNA Damage Checkpoint Response...
questionsmedicales.fr › Phénomènes génétiques › Réplication de l'ADN › Phase S › A Noncanonical DNA Damage Checkpoint Response...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › A Noncanonical DNA Damage Checkpoint Response...
questionsmedicales.fr › Eucaryotes › Champignons › Ascomycota › Saccharomycetales › A Noncanonical DNA Damage Checkpoint Response...