Novel response to neoadjuvant anti-PD1 therapy for a patient with retrocaval melanotic schwannoma.
Journal
Melanoma research
ISSN: 1473-5636
Titre abrégé: Melanoma Res
Pays: England
ID NLM: 9109623
Informations de publication
Date de publication:
01 02 2021
01 02 2021
Historique:
pubmed:
17
12
2020
medline:
2
9
2021
entrez:
16
12
2020
Statut:
ppublish
Résumé
Melanotic schwannoma is a rare nerve sheath tumor composed of melanin-producing Schwann cells with the potential for metastasis. These tumors can be associated with familial tumor syndromes and can cause significant symptoms related to nerve compression and mass effect. Due to the rarity of these lesions, they can be initially misidentified as melanocytomas, pigmented dermatofibrosarcoma protuberans, neurofibromas or malignant melanomas. Surgical excision is the mainstay of treatment with limited benefit from adjuvant systemic chemotherapy or radiation. Modern treatments with immune checkpoint blockade have demonstrated significant improvements in progression-free and overall survival for a variety of cancer histologies; however, anti-PD1 therapy has yet to be evaluated in patients with melanotic schwannoma. This report demonstrates a significant improvement in symptomatology and tumor stability with neoadjuvant anti-PD1 therapy for a retrocaval melanotic schwannoma initially masquerading as malignant melanoma. This report demonstrates the potential benefit of a novel therapeutic option for patients with melanotic schwannoma.
Identifiants
pubmed: 33323721
pii: 00008390-202102000-00012
doi: 10.1097/CMR.0000000000000711
pmc: PMC7755705
mid: NIHMS1647721
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
92-97Subventions
Organisme : NCI NIH HHS
ID : K12 CA139160
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007019
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007281
Pays : United States
Informations de copyright
Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
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